Category: Health

Glycemic load and fertility

Glycemic load and fertility

Toxicol Res loax 26 : — Energy-enhancing supplement Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Kanooka Grove, Clayton, VICAustralia. Fertil Steril ; : —

Jessica A Grieger and Lisa J. Moran contributed equally as Holistic weight loss supplements senior authors.

Preconception diet is a proposed modifiable Gkycemic factor for infertility. However, there is no official guidance for women in the preconception period as to lload dietary approaches may improve fertility. A Energy-enhancing supplement synthesis of the lowd evidence Glyycemic key to determine the ad effective dietary patterns and fergility as well as evidence Diabetic nephropathy treatment options, and to provide information for nutritional recommendations for couples planning a laod.

In this systematic scoping Glyce,ic, four electronic databases Medline and EMBASE via Ovid processing, CAB Direct, and Energy healing methods via EBSCO were searched for observational studies Glycemic load and fertility and retrospective cohort, cross-sectional, and case—control studies from inception Greek yogurt for diabetics Weight loss tips September Eligible studies included women of reproductive age Glycemic load and fertility the preconception period, and evaluated exposures related to preconception diet and outcomes related to fertility.

Results Holistic wellness coaching synthesized using a descriptive fertliity. A total of 36 studies were eligible for Energy-enhancing supplement 31 prospective, 3 An, and 2 case—control studies and were published between and Of the fertipity dietary exposures, increased adherence to Glycemic load and fertility Mediterranean diet displayed the strongest and most consistent association with improved Glycemkc pregnancy rates.

Reducing trans fatty acids TFAssaturated fatty Glycmeic, and discretionary food intake fast food fegtility sugar-sweetened beverages were associated with improvements nad live birth, clinical pregnancy rates, and related ART outcomes.

Loaf dietary components of seafood, dairy, Glycemuc soy demonstrated inconsistent Managing Diabetes effectively across the few included studies.

Due ad heterogeneity laod the limited available literature on most exposures, there is insufficient evidence to support any specific dietary approach Ink cartridge refill improving fertility.

However, following some of Weight loss tips dietary approaches outlined in this review anti-inflammatory diets, reducing TFA, and discretionary Glycwmic intake Omega- fatty acids for inflammation consistent anv broad healthy eating guidelines, have little anf no associated risk, and offer a plausible set of fertilitg benefits.

This warrants further exploration in randomized controlled trials. Infertility is loaf as the failure to successfully conceive after more than 1 year of unprotected intercourse Tabong and Adongo, Infertility affects fertulity million couples and million individuals globally Word Health Organisation, Blood sugar control and cancer prevention Infertility places abd heavy burden fertilihy couples fertiility wish to conceive, fergility negative psychological sequelae including anxiety, Glhcemic, and stress Yusuf, This is fedtility coupled with significant fertklity and economic challenges.

Therefore, there is ad need for Supporting blood sugar balance with supplements simple and inexpensive modifiable risk factors to be explored as Glyemic new or adjunct avenues to fertility treatment. Gllycemic lifestyle-related risk factors, such as suboptimal preconception fegtility, obesity, anxiety, and stress, are consistently Energy-enhancing supplement with a higher likelihood of infertility Glhcemic poor fertility outcomes Dağ fertiility Dilbaz, ; Ferrtility et al.

Preconception fertiliy is a key modifiable risk factor for infertility, Energy-enhancing supplement, with many women having inadequate nutritional Glycemic load and fertility in the fertliity period Awoke et al.

This has generated considerable interest around Hydration for sports performance optimization relevance of diet to reproductive health. Several cross-sectional Glyccemic prospective studies Glydemic indicated that loac preconception dietary patterns to align with international food-based aand guidelines may be beneficial for fertility and reproductive outcomes such as ovulation and menstrual regularity in a efrtility of geographical populations Chavarro et al.

Limiting intake of discretionary foods which ferrility higher amounts of trans TFAs and saturated fertiligy acids SFAssodium and free sugars, while promoting intake of Glyce,ic fats and core foods such as whole grains, dairy, vegetables, and fish, may ferhility reproductive success Herforth et al.

Whilst the exact mechanism in which these core food components improve fertility are largely unknown, the increased inflammation and oxidative stress from higher intakes of discretionary choices are thought to play a key role for poorer fertility outcomes Ley et al.

Despite growing acceptance that diet is associated with reproductive outcomes in women, there remains no official guidance for women in the preconception period regarding which dietary or duration approaches to follow for optimal fertility.

Synthesizing the relevant evidence and identifying key dietary patterns and components is pertinent to developing knowledge in this field and providing an evidence base to assist with formulating evidence-based nutritional recommendations for couples planning a pregnancy.

Due to the lack of randomized controlled trials RCTs assessing specific dietary components or patterns in nutrition research for the purposes of improving fertility outcomes, using existing observational evidence can aid in identifying targets to assess in future intervention studies Ioannidis, Therefore, the purpose of this scoping review is to examine the extent and range of observational research undertaken to evaluate the effect s of preconception dietary intakes and patterns on fertility outcomes.

The research question for this review is: What is the relationship between preconception diet and female fertility? Eligibility was determined using the Participant-Exposure-Comparison-Outcome PECO framework, defined a priori in the protocol, which is registered on the Open Science Framework OSF database Participants included women of reproductive age, specifically during pre-conception or inter-conceptionpregnancy, and post-partum periods.

Preconception was defined as the time when planning a pregnancy, and inter-conception was defined as the time in-between pregnancies. Pregnant and post-partum women were included when preconception behaviours were retrospectively assessed. Dietary or nutritional components i. whole diets, dietary patterns, food groups, or individual foods were included as relevant exposures.

Trials based solely on micronutrients, caffeine or alcohol, and studies with the stated goal of weight loss were excluded. Studies were included if they reported any of the following outcomes: anovulatory or ovulatory fertility, conception via ART, pregnancy rate clinical or biochemicallive birth rate, time to conception natural or via ARTfecundity, ovulation, menstrual regularity, ART outcomes e.

fertilization rate, implantation rate, number of oocytes retrieved, number of cyclesstillbirth, miscarriage, or adverse ART outcomes e. ovarian hyperstimulation syndrome, early pregnancy loss, multiple pregnancies. The search strategy, including database selection and search terms MeSH headings and keywordswas developed via consultation with experts in fertility or nutrition or scoping review methodology, and an expert medical librarian.

A variety of keywords, relating to preconception, diet, and fertility, were used in the search strategy Supplementary File S1.

The following databases were searched: MEDLINE OvidEMBASE OvidCAB Direct, and CINAHL Plus EBSCO. All sources were searched from inception to 27 September We also included additional studies based on expert opinion that were not identified in the original search.

No studies were excluded due to being in a language other than English. Screening was undertaken using Covidence www. Title and abstract screening were assessed in duplicate by several reviewers S.

Data were extracted S. and J. As the role of scoping reviews is to represent the scope or coverage of a body of literature over time, it was not required to assess the study quality of the literature Munn et al.

Of the 16 articles identified, were removed as duplicates, leaving 15 studies for screening. After initial screening, there were full texts assessed for eligibility, with eight records not being retrieved.

This screening resulted in 36 studies being included in the scoping review Fig. Most of the included studies were prospective by design Chavarro et al.

Figure 2 details the number of studies relevant to energy and macronutrients, core food groups, discretionary food groups, phytoestrogens, or whole diet approaches, split by populations using or not using ART.

Twelve studies included core food groups, i. Three studies included phytoestrogens. Several exposures utilizing a whole of diet approach were also included; i.

The number of included studies regarding ART or spontaneous conception with the various primary or secondary exposures related to the main categories of diet-related categories. Figure 3 stratifies the number of outcomes for both spontaneous and ART outcomes in the included studies.

The number of included studies for the reported outcomes among the populations. A women conceiving spontaneously and B women conceiving with ART.

One prospective cohort study of spontaneously reproducing women examined energy density Hartman et al. Results for fertility outcomes stratified by nutritional component in spontaneously conceiving women.

NS: total fat, cholesterol, most FAs Chavarro et al. NS: marine-sourced long chain fatty acids Wise et al. NS: low, high-fat dairy Wise et al. NS: fruits, vegetables Revonta et al. NS: vegetable Grieger et al. NS: diet soda Machtinger et al.

NS: sugar-sweetened fruit juice and energy drinks Hatch et al. Two prospective cohort studies assessed protein intake, one focussing on either the source of protein vegetable or animal source in 18 spontaneously reproducing women Chavarro et al.

However, Nassan et al. Unprocessed red meat intake beef, pork, or lamb as the main mealassessed as a continuous variable, was not associated with live birth rates.

However, when comparing the lowest category of intake no unprocessed red meat intake compared to 0. Results for fertility outcomes stratified by nutritional component in women conceiving via ART. NS: total meat intake, eggs, vegetable source of protein Nassan et al.

NS: total omega-3 consumption Salas-Huetos et al. NS: full-fat or low-fat dairy Afeiche et al. NS: Noli et al. NS: Embryo transfer Noli et al. Chiu et al.

NS Sun et al. NS Karayiannis et al. NS: embryo quality Vujkovic et al. NS: number of good-quality embryos, good-quality oocytes, embryo transfer Ricci et al. NS Jahangirifar et al.

NS: embryo transfer Diba-Bagtash et al. The SF and PRESTO cohorts reported that increasing glycaemic load and total carbohydrates were associated with reduced fecundity Willis et al. In women undergoing IVF, there was no association between dietary carbohydrate intake and glycemic load with clinical pregnancy rates Table 2.

Five studies assessed total fat and fatty acids on fertility outcomes. Higher total fat consumption was not associated with ovulatory infertility Chavarro et al.

However, consumption of specific fatty acids had varying and inconsistent effects on fertility outcomes. Similar inconsistent results were reported for fecundity. In the SF and PRESTO cohorts, fecundity was lower in women who were in the highest level of TFA intake compared to the lowest level in the PRESTO Q4 vs Q1, FR: 0.

Similarly, higher saturated fat intake was related to lower fecundity in the North American Q4 vs Q1, FR: 0. Higher omega-3 was associated with improved fecundity Q4 vs Q1, FR: 1.

: Glycemic load and fertility

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For the second study, published in the July issue of Obesity Reviews, researchers reviewed 60 studies that had investigated the relation between weight status and sperm quality. The combined analysis found that overweight and obesity were linked to lower sperm quality e.

Obesity may also cause low sperm quality through increased production of harmful free radicals and inflammatory compounds. Keep in mind, both of these evidence reviews included observational studies and therefore do not prove causality.

Eating a Mediterranean diet e. In men, the DASH diet, which features beans and lentils, nuts, whole grains, fruits, vegetables, fish, poultry and low-fat dairy, has been associated with improved sperm counts.

On the other hand, a typical Western diet, higher in red meat, saturated fat and refined carbohydrates, has been tied to lower sperm quality.

Eating a diet that emphasizes whole grains, fruits and vegetables, plant proteins, fish, poultry and unsaturated fats, and limits refined starches and added sugars, red meat and saturated fat can help prevent overweight and insulin resistance. It can also help guard against high blood pressure, high cholesterol, type 2 diabetes, heart disease, stroke and dementia.

Leslie Beck, a Toronto-based private practice dietitian, is Director of Food and Nutrition at Medcan. Report an error. Editorial code of conduct.

Authors and topics you follow will be added to your personal news feed in Following. This is a space where subscribers can engage with each other and Globe staff. Non-subscribers can read and sort comments but will not be able to engage with them in any way. Click here to subscribe. If you would like to write a letter to the editor, please forward it to letters globeandmail.

Readers can also interact with The Globe on Facebook and Twitter. While the study occurred in a single center, the gains made between the highest and lowest quartile are astonishing for their size and consistency.

At the moment, the data on how red meat and white meat impact fertility is mixed, but on balance it is negative, especially in the case of processed red meat.

As you can see below, the opposite was true with vegetable consumption. For men, the better run studies seems to suggest consuming poultry is of little harm.

On the other hand consuming processed red meats like sausage or baloney is more closely associated with issues than eating unprocessed red meats like a piece of chicken or steak. Amongst women trying to conceive naturally, greater seafood intake correlates with better fertility.

Below is a study of couples tracking their Time To Pregnancy based on seafood and fish consumption. However, the greatest benefit was conferred when both members of a couple ate 8 or more servings per cycle.

As you can see below, the cumulative odds of conception after each menstrual cycle is higher for the couples where both partners consume high levels of seafood and seafood rather than when just one partner does. All the same, some of the benefit of consuming seafood can be diminished if that seafood has been exposed to pollutants or mercury.

As a result, where the seafood is caught, and what type it is, matters. A good illustration of this are two similar studies performed in Sweden which has cleaner waters and in the Lake Ontario region more contaminated waters that looked at local fish consumption and time to pregnancy.

Today the American College of Obstetricians and Gynecologists recommends that women who are trying to conceive eat two to three servings of fish per week but limit their fish composed of high levels of mercury. Items like canned tuna are of moderate risk and should only be eaten once per week.

Within an IVF population, the Brazilian study we referenced earlier noted that women who consumed greater levels of fish recorded higher levels of blastocyst embryos embryos most likely to lead to a live birth , but that did not translate into a higher predicted rate of pregnancy. The data on the impact of dairy on fertility is contradictory.

We have two good studies on the subject. In the second trial, when the investigators of the Nurses Health Study tracked women who had trouble conceiving due to ovulatory dysfunction, they noticed women with a high intake of high fat dairy were more likely to be able to ovulate and conceive than women with a high intake of low fat dairy.

Specifically, whole milk appeared to be associated with better ovulation while low fat yogurt, frozen yogurt, and sherbert were associated with more ovulation issues.

Amongst women undergoing IVF , the best study on the subject followed over women and determined in women 35 and over higher daily dairy intake closely associated with increased rates of success, especially at rates of over 3 servings per day amongst younger women it had no correlation to success.

Soy and its impact on fertility has been controversial for some time largely because in animals like cows and cheetahs soy intake has been closely correlated with infertility.

However, in humans the data pretty clearly demonstrates that soy intake in women does no harm when trying to conceive naturally and in high quantities, through supplements, is helpful when a woman must resort to ovulation induction, IUI or IVF. To understand what it takes to follow a Low GI diet here is a sample menu from the study for Low GI vs healthy eating plans for PCOS.

As you can see, the difference between low GI and usual diet is nothing too crazy. There are subtle changes, like swapping, higher GI foods to lower ones: whole-meal bread with whole grain bread or having an apple instead of banana.

The above meal plan has some issues. Namely the use of low-fat dairy and breakfast cereal. Studies have shown that full-fat dairy is actually better for ovulation and breakfast cereals should be avoided. The above graph shows the scale of improvements women recorded themselves eating low GI LGI vs conventional healthy diet CHD.

A higher column reflects a greater change in each domain. In this study, better blood sugar control helped more women to ovulate regularly. Furthermore, this way of eating reduces inflammation. We should not forget that in this study authors compared two rather healthy food plans.

I assume the difference would be even more dramatic if women were allowed to have what they usually eat. A recent systematic review and meta-analysis compared how low GI weigh up to High GI diets for overweight women with PCOS.

Low GI won in all key areas:.

How Your Diet May Impact Your Fertility

The above graph shows the scale of improvements women recorded themselves eating low GI LGI vs conventional healthy diet CHD. A higher column reflects a greater change in each domain.

In this study, better blood sugar control helped more women to ovulate regularly. Furthermore, this way of eating reduces inflammation. We should not forget that in this study authors compared two rather healthy food plans. I assume the difference would be even more dramatic if women were allowed to have what they usually eat.

A recent systematic review and meta-analysis compared how low GI weigh up to High GI diets for overweight women with PCOS. Low GI won in all key areas:. Low GI was equally beneficial for women with and without PCOS.

Study participants lost weight and their bodies controlled sugar better. If you are ready to give low GI foods a go, a good place to start is the website of the University of Sydney. Here you will find low GI food recipes, ingredient swaps and get plenty of inspiration.

A searchable database for low GI and GL fertility foods is here. Glycemic load Another handy measure when using low GI foods is the glycemic load. Dairy has been identified as having a neutral to beneficial effect on fertility and inflammation Nieman et al. There have been some reports of potential deleterious effects of soy phytoestrogens on reproductive outcomes in non-human mammals Seppen, This has not been confirmed in human RCTs where the observed benefits of isoflavones include increased endometrial thickness and clinical pregnancy rates in patients undergoing uterine insemination Unfer et al.

There have also been reports that phytoestrogens when supplemented in the luteal phase may improve the implantation and clinical pregnancy rates in women undergoing IVF Unfer, Casini, Gerli et al. In spite of these promising findings, we did not observe these reports in this scoping review. The lack of consistent beneficial association of fruits, vegetables, and whole grains with fertility was surprising given the numerous vitamins, minerals, trace minerals, bioactive nutrients, antioxidants, or non-nutrient components present in these foods Gutteridge and Halliwell, ; Blomhoff, , as well as prior reports of whole grains being associated with endometrial thickness on the day of embryo transfer and improved embryo receptivity and implantation Gaskins et al.

This may reflect the overall limited number of included studies for these dietary exposures. This scoping review offers the most comprehensive and up-to-date search that overviews current observational evidence of the relationships between diet and fertility and evidence gaps that must be filled prior to adoption into clinical practice.

Limitations identified in this review include heterogeneity in comparators, exposures and confounders, and observational data precluding causation and making it difficult to reach definitive conclusions on any proposed associations.

However, we purposely examined observational studies with the intention of guiding and generating hypotheses for future interventional research. This is a key benefit of observational data and one which should not be underestimated.

Indeed, prior systematic reviews have highlighted that existing RCTs examining lifestyle and fertility report on general healthy lifestyle changes only Lan et al. It should also be noted that much of the currently available evidence is not suitable for controlled human studies or RCT designs, and, in this context, observational studies offer considerable insights into the potential benefits or harms, or lack thereof, of specific diets and dietary components for fertility.

Another limitation is that the majority of findings identified herein were derived from a small number of studies and further observational data may be required to inform the design and execution of intervention studies.

The limited number of observational studies also precluded sub-group analysis in women with different aetiologies of fertility such as polycystic ovary syndrome PCOS or endometriosis and prohibits the pooling of data in meta-analysis.

Despite these limitations, there is emerging literature on the relationship between diet and PCOS and endometriosis, which may allow for more stratified sub-group analyses in future.

While it is important to assess individual dietary changes, foods are not eaten in isolation and there are likely important additive or synergistic effects of different nutrients in a whole diet setting that were not captured in the included studies.

This may partly explain the reason for the consistent evidence found in holistic dietary approaches predominantly, the MedDiet compared to the nutrient-specific assessments included in this review.

Moreover, the way different diets are analysed in a specific study may impact the results. For example, some dietary pattern studies included in this review adopted a data-driven approach Vujkovic et al. Therefore, discrepancies across studies may reflect differences in methodology rather than actual inconsistencies in the effect of the exposure.

The heterogeneity in geographical origin of these studies similarly impacts the interpretation of these results. Different geographic locales have varying environmental factors influencing production and consumption of food climate, religion, and culture , and therefore impacting the influence of these dietary exposures in certain patient populations.

Moreover, language barriers, specifically in observational studies where the diet is self-reported, may result in classification bias. While there was a wide array of geographical locales investigated, most of the studies were conducted in developed countries The West, Europe, and Scandinavia , precluding appropriate assessment of these dietary exposures in disadvantaged populations.

Importantly, many included outcomes were in line with the core outcomes set for infertility Duffy et al. However, these were inconsistently reported across the various dietary exposures and between spontaneous and ART populations. There was also variation in the definitions used to assess infertility e.

some defined reduced fecundity as higher time to pregnancy using TRs, whereas others assessed fecundity using probability regression modelling to assess the per-cycle probability of conception which increases opportunities to engage in selective outcome reporting Duffy et al.

Core outcomes such as gestational age at delivery or core safety measures in ART studies such as neonatal mortality or major congenital anomaly were not reported. Therefore, there is a need for further nutrition-based research on fertility to standardize outcomes and assessment.

Adherence to the MedDiet and reducing TFA and discretionary foods, show potential benefit in improving fertility outcomes for both spontaneous and ART pregnancies. Seafood, dairy and soy demonstrated inconsistent findings across the few included studies.

Supplementary data are available at Human Reproduction Update online. No new data were generated or analysed in support of this work. All data are available via published manuscripts cited in this manuscript. assisted in title and abstract screening.

assisted in full-text screening, data extraction. provided intellectual input. reviewed and synthesized the extracted data and wrote the first draft of the manuscript with assistance from J.

conceptualized and determined the scope of the manuscript and supervised the review process. All authors meet ICMJE criteria for authorship and approved the final version for publication. This work received no specific funding. is supported by a Monash University Faculty Graduate Research Stipend.

is supported by a Heart Foundation of Australia Future Leader Fellowship. is supported by a Peter Doherty Biomedical Research Fellowship provided by the National Health and Medical Research Council NHMRC of Australia.

is supported by a National Health and Medical Research Council NHMRC grant APP Afeiche MC , Chiu YH , Gaskins AJ , Williams PL , Souter I , Wright DL , Hauser R , Chavarro JE ; EARTH Study Team.

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Associations between red meat intake and biomarkers of inflammation and glucose metabolism in women. Am J Clin Nutr ; 99 : — Lin W-T , Kao Y-H , Sothern MS , Seal DW , Lee C-H , Lin H-Y , Chen T , Tseng T-S. The association between sugar-sweetened beverages intake, body mass index, and inflammation in US adults.

Try incorporating complex carbohydrates into your diet. Eat foods with fiber like fruits, vegetables, beans and whole grains. Plant proteins come from beans, nuts, seeds and tofu.

In addition to creating a fertility diet plan, you should also be mindful of your weight. Stay active and exercise while you eat right. Keep up with the latest news and information about fertility by checking in with our blog every week. We post everything you need to know about your fertility treatments journey.

diet , fertility , nutrition. Wade Resource Patient Portal.

Blood Sugars and Fertility: Glycemic Index, Glycemic Load and Insulin Resistance Watermelon is unprocessed. More from Oxford Academic. At the moment, the data on how red meat and white meat impact fertility is mixed, but on balance it is negative, especially in the case of processed red meat. Lots of evidence suggests that insulin sensitivity may be a key factor in ensuring ovulation and maintaining fertility. All the same, some of the benefit of consuming seafood can be diminished if that seafood has been exposed to pollutants or mercury. Obstet Gynaecol Res ; 47 : —
Glycemic load and fertility

Author: Yozil

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