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The Truth About Forskolin in less than 5 minForskolin and scientific research -
We have previously reported that forskolin kills U cells by inhibiting the JAK-STAT pathway 10 and here we could show that forskolin alone or in combination with dexamethasone, melphalan or bortezomib Fig. Combined disruption of ERK-signaling and the JAK-STAT pathway is required to induce apoptosis of MM cells in the presence of BMSCs Hence, by demonstrating the inhibition of both signaling pathways, the results of the present study support the clinical potential of combining forskolin with conventional therapeutic agents.
Natural compounds such as forskolin are often considered to be affordable and, although not necessarily true, to have low general toxicity As many natural compounds have the advantage of targeting multiple signaling pathways 48 , 49 , 50 , 51 , a growing number of clinical studies are now evaluating their potentials in cancer treatment in combination with conventional chemotherapies The present study opens for clinical studies along the same lines.
The natural compound forskolin has for centuries been applied in traditional medicine 15 and its safety has also been documented in conventional modern medicine We suggest that forskolin, by targeting multiple signaling pathways in MM cells, might reduce the doses of chemotherapeutic agents required to kill such cells in vivo and thereby limit the severe side effects associated with current conventional therapies of MM.
How to cite this article : Follin-Arbelet, V. et al. The natural compound forskolin synergizes with dexamethasone to induce cell death in myeloma cells via BIM. Parkin, D. Global cancer statistics, CA Cancer J.
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Uzoigwe, J. Cancer prevention and treatment using combination therapy with plant- and animal-derived compounds. Download references. The work was supported by grants from the Norwegian Cancer Society, the Jahre Foundation, the Blix Family Foundation, the Research Council of Norway, K.
Jebsen Foundation for Medical Research and the University of Oslo. The authors are grateful to Camilla Solberg and Jannicke Holmseth for excellent technical help. Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, PO Box Blindern, Oslo, N, Norway.
KG Jebsen Center for Myeloma Research and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, N, Norway. You can also search for this author in PubMed Google Scholar. designed the research, performed experiments, analyzed data and wrote the paper; K.
designed the research, performed experiments and wrote the paper; H. performed experiments and helped in writing the paper, E. helped designing the research, analyzing the data and writing the paper.
helped designing the research, provided material and helped in writing of the paper; H. designed the research, analyzed data and wrote the paper. All authors have read and approved the manuscript. and H. performed experiments; V.
designed the research; A. provided primary sample material; V. analyzed data; V. wrote the paper. All authors reviewed the manuscript. This work is licensed under a Creative Commons Attribution 4.
Reprints and permissions. Sci Rep 5 , Download citation. Received : 29 October Accepted : 30 June Published : 26 August Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.
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Skip to main content Thank you for visiting nature. nature scientific reports articles article. Download PDF. Subjects Apoptosis Cancer therapy Cell signalling Myeloma. Abstract We have previously demonstrated that activation of the cyclic adenosine monophosphate cAMP pathway kills multiple myeloma MM cells both in vitro and in vivo.
Cell Lines and Cell Culture The human myeloma cell lines HMCLs U, NCI-H, RPMI and OPM-2 were purchased from the American Type Culture Collection ATCC, Manassas, VA, USA. Small interference RNA transfections Control siGenome Non-Targeting pool siRNA D and BIM small interfering RNA siRNA D, D, D and D were obtained from Thermo Fisher Scientific Biosciences GmbH St.
Analysis of Cell Death by Flow Cytometry Flow cytometry analysis was performed on a FACSCalibur BD Biosciences. ScanR Viability Assay This assay was performed as described previously Determination of synergism by the combination index CI method The interaction of forskolin and dexamethasone was determined by combination index CI method 27 using the CompuSyn software program ComboSyn Inc.
Figure 1. Dose dependent cell death induced by forskolin in five different HMCLs. Full size image. Figure 2. Figure 3. Combination of low doses of forskolin and dexamethasone induces synergistic cell death in HMCLs.
Figure 4. Combination of low doses of forskolin and dexamethasone enhances the expression of BIM. Figure 5. Figure 6. Effect of forskolin in combination with conventional therapeutic agents on primary MM cells. Discussion Despite the development of new combination therapies during the past 15 years, the majority of multiple myeloma patients relapse, their tumor cells become chemoresistant and they die from the disease.
Additional Information How to cite this article : Follin-Arbelet, V. References Parkin, D. Article Google Scholar Laubach, J. Article CAS Google Scholar Rajkumar, S. Article Google Scholar Palumbo, A.
Article CAS Google Scholar Mateos, M. Article Google Scholar Gay, F. Article Google Scholar Mahindra, A. Article CAS Google Scholar Follin-Arbelet, V. Article CAS Google Scholar Krett, N. CAS PubMed Google Scholar Follin-Arbelet, V. Article CAS Google Scholar Klein, B.
CAS PubMed Google Scholar Klein, B. CAS PubMed Google Scholar Rickles, R. Article CAS Google Scholar Seamon, K. Article CAS ADS Google Scholar Valdés, L. Article Google Scholar Laurenza, A.
Additionally, in Europe, there have been reports of acute poisoning following consumption of products containing forskolin, possibly due to contamination. Consequently, it is important to be cautious with any supplement or herb, as they are not monitored by the FDA and could have issues with purity, quality, or dosage.
Aside from the risk of contamination, forskolin can pose risks for certain groups and should not be taken by the following:. Forskolin is not a weight loss miracle drug, and there is no substitute for proper diet and exercise. If, after following a healthful, low calorie diet and exercise program, a person is not losing weight, they may want to consult their doctor.
The medical professional can recommend ways to help with weight loss, but forskolin is probably not going to be one of them. Although obese participants had higher levels of hunger and satiety hormones after 2 years of sustained weight loss, hunger hormones seemed to be….
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Medical News Today. Health Conditions Health Products Discover Tools Connect. Can forskolin help me lose weight? Medically reviewed by Debra Rose Wilson, Ph. What is forskolin? How does forskolin work in weight loss? What are the suggested uses of forskolin?
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Read more about our vetting process. Was this helpful? Fast facts on forskolin: Forskolin is a supplement made popular for its possible use in weight loss. Forskolin comes from a plant called Coleus forskohlii.
In theory, forskolin aids weight loss by helping create enzymes called lipase and adenylate cyclase. Share on Pinterest Forskolin is a weight loss supplement derived from a plant. Share on Pinterest Studies on the weight loss benefits of forskalin have produced mixed results.
Risks and benefits. Share on Pinterest Although forskolin is not known to interact with any existing conditions, caution is still advised. Those taking blood thinners or medication for low blood pressure should avoid forskalin.
How we reviewed this article: Sources. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles.
You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Share this article. Latest news Ovarian tissue freezing may help delay, and even prevent menopause. RSV vaccine errors in babies, pregnant people: Should you be worried?
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Forskolin and scientific research myeloid leukemia Forskolin and scientific research is an aggressive hematological malignancy occurring very often in researrch adults, Fogskolin poor Beetroot juice and hair growth depending on both rapid disease progression and drug resistance occurrence. Therefore, new therapeutic approaches are demanded. Epigenetic marks play a relevant role in AML. GSKJ4 is a novel inhibitor of the histone demethylases JMJD3 and UTX. To note GSKJ4 has been recently shown to act as a potent small molecule inhibitor of the proliferation in many cancer cell types. Progressive fat burning Forskolin and scientific research to be disabled in Antioxidant-rich fruits browser. Forskolin and scientific research Forsolin best experience on our site, be sure to turn on Javascript in your browser. Scientiric is a cell permeable activator and has been used to potentiate neuron differentiation as well as maintain human ES cells in a naïve or ground state. Forskolin induces differentiation of various cell types and activates pregnane X receptor PXR and FXR. Forskolin exerts an inotropic effect on the heart, has platelet antiaggregatory and antihypertensive actions.
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