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Pycnogenol for allergies

Pycnogenol for allergies

The Pycnogenll of asthma symptoms Pycnogenol for allergies rated on a Sports drink options point scale. Alldrgies of use Chronic venous insufficiency : Pycnogenol seems Pycnogejol reduce leg pain and allegries, and edema Aloergies used for 3 to 12 weeks. The researchers speculate that a lag-time of at least five weeks prior to pollen exposure is required for Pycnogenol® to defy hay-fever symptoms. Pycnogenol® is a registered trademark of Horphag Research Ltd. With the limited number of 39 patients statistical predications were unattainable. In addition, the patients were able to reduce the use of their salbutamol asthma inhaler per day by half.

Pycnogenol for allergies -

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Pycnogenol® normalizes immune response In human studies Pycnogenol® has shown diverse anti-inflammatory activity [Grimm et al. Pycnogenol® has antihistaminic potency Pycnogenol® was found to dose-dependently inhibit the release of histamine from mast cells challenged with an irritant [Sharma et al.

Pycnogenol® for management of asthma A double-blind, placebo-controlled, cross-over study has investigated the effect of Pycnogenol® in 22 patients 50 year of age , suffering from asthma since 1 and up to 16 years [Hosseini et al.

Pycnogenol® for management of childhood asthma The vast majority of asthmatics have developed the disease already during childhood, most of them before they reached the age of five years.

Summary Pycnogenol® offers help for the management of allergic rhinitis and asthma: Demonstrated immune modulation in humans Controlled clinical trial with asthmatic patients Controlled clinical trial demonstrating efficacy in childhood asthma References Grimm T et al.

Inhibition of NF-kB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract Pycnogenol®. J Inflamm 3: , Hosseini S et al. Pycnogenol® in the management of asthma.

Journal of Medicinal Food, 4: , Lau BHS et al. Pycnogenol® as an adjunct in the management of childhood asthma. J Asthma , Rohdewald P. A review of the French maritime pine bark extract Pycnogenol® , an herbal medication with a diverse pharmacology.

Int J Clin Pharmacol Ther 40 4 : , Sharma SC et al. Pycnogenol® inhibits the release of histamine from mast cells. AkzoNobel Launches New Multi-substrate Primer for Plastic Automotive Exterior.

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Additionally, the study participants rated their asthma symptoms regarding severity. Furthermore, Pycnogenol significantly reduced proinflammatory mediators leukotrienes in the blood of patients when compared with both baseline values and the placebo.

Most asthmatics develop the disease during childhood, often before reaching the age of 5. A double-blind, placebo-controlled study investigated the effect of Pycnogenol on 60 children aged 6—18 with mild to moderate asthma. The study showed that their breathing capacity improved significantly after 1 month of treatment with Pycnogenol as assessed by measuring FEV1.

The severity of asthma symptoms as well as leukotriene levels in their urine decreased drastically after 1 month of Pycnogenol supplementation … and further decreased significantly throughout the trial period.

Treatment with a placebo had no significant effect on leukotriene levels or asthma symptoms. The most compelling outcome of the study was the dramatically reduced necessity to use albuterol rescue inhalers; severe asthma attacks occurred much less frequently Figure 2.

The effects of Pycnogenol on allergic asthma was investigated in a 6-month study with 79 patients who suffer from dust mite allergy.

In addition, the patients were able to reduce the use of their salbutamol asthma inhaler per day by half. The authors of the three studies concluded that Pycnogenol is an effective and safe nutritional approach to manage mild-to-moderate chronic asthma and to reduce the need for rescue medication.

Inflammatory processes are a key mechanism in asthma development. After 5 days of daily intake, a study reported that Pycnogenol significantly prevented the upregulation of the proinflammatory enzymes 5-LOX and COX Some of these molecules are known to play an important role in the onset of asthma.

The partial inhibition of NF-κB lowers the sensitivity level for triggering an immune response, which will help to prevent an asthmatic attack. MMP-9 is a connective tissue degrading enzyme, which greatly affects the pulmonary function of asthmatic patients.

In a similar study, statistically significant inhibition of inflammatory molecules COX-1 and COX-2 was observed after consuming mg of Pycnogenol. These anti-inflammatory effects of Pycnogenol were confirmed in a study with immune cells macrophages that are involved in allergic reactions.

Laboratory data and results from clinical trials suggest an amelioration of allergy symptoms after Pycnogenol intake. In a randomised, double-blind, placebo-controlled trial, researchers found that Pycnogenol supplementation improved allergic rhinitis symptoms from birch and other pollen when the supplementation started at least 5 weeks before the pollen season.

Another study investigated the effects of Pycnogenol intake on wheal and flare evolution after local histamine injection in healthy individuals. Pycnogenol was found to reduce the release of histamine from the immune cells mast cells dose-dependently Figure 3.

Interestingly, Pycnogenol was at least as effective at inhibiting histamine release as a widely used antihistaminic medication sodium cromoglycate.

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