Presented at the World Sleep Congress, held October , in Rio De Janeiro, Brazil, Naylor and colleagues assessed TAK in healthy adult men, aged between 18 and 40 years.

The high-dose TAK group received 30 mg dose followed by 10 mg, while the low-dose group received 15 mg followed by 5 mg. The unequal doses of the therapy were given 4 hours apart at 11pm and 3am, and patients stayed awake during each treatment period starting before dosing on day 1 until completion of the assessments, approximately 10 hours after the first dosage.

Investigators had a minimum of 7 days between treatment period for an appropriate washout of study drug and normalization of sleep-wake cycles. TAK also showed a favorable safety profile, with no instances of severe adverse events, fatalities, or treatment discontinuations because of adverse events reported.

We are encouraged by these results, which have demonstrated the efficacy and safety of TAK in the tested doses, both high and low, among the participants," Naylor told. READ MORE: Novel Insights on Orexin Receptor TAK and its Discontinued Narcolepsy Study.

Throughout the study, investigators assessed safety as well as pharmacokinetic and pharmacodynamic parameters, assessed up to approximately 10 hours after the first dose in each treatment period.

The measurements for sleepiness were analyzed with the MWT, at predose and 2, 4, 6, and 8 hours post-first dose, and KSS, at predose and after each MWT session. Among the total number of patients, 10 The groups that received both TAK high and lose dose regimens had mean plasma concentrations that peaked between 3 and 5.

Investigators noted that systemic drug exposures increased approximately proportionally with dose and most participants achieved the maximum MWT sleep latency of 40 minutes with TAK These findings indicate TAK could offer a promising new approach for addressing excessive daytime sleepiness in a wide range of disorders in which orexin levels are presumed to be normal," Naylor told.

As for safety measures in the study, 6 The 1 moderate TEAE was noted as increased blood creatine phosphokinase in a patient given a low dose of TAK but was deemed unrelated to the study drug.

Overall, investigators had no reports of deaths, serious TEAEs, TEAEs leading to discontinuation, or severe TEAEs in the study with TAK Of note, 3 We currently have 2 placebo-controlled phase 2 ongoing trials to further investigate TAK in sleep disorders: one study on narcolepsy type 1 and one on narcolepsy type 2.

We also have an extension study for participants who complete these trials to start or continue taking TAK if they want to; this extension study will help us to understand the safety of TAK over a longer period of time," Naylor told.

We look forward to sharing the results of these studies at a later date and to the continuous progress toward larger and longer clinical trials in patients with sleep-wake disorders and other populations.

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A paper found caffeine can reduce how much deep sleep you get and how much sleep you get overall. The closer to bedtime you consume caffeine, the more it can reduce your sleep time.

Drinking a coffee and then taking a short nap — sometimes called a nappuccino — can wake you up fast. But you want to use this energy booster cautiously and sparingly.

Drinking coffee too late in the day can impact your nighttime sleep, tanking your energy levels the next day. Research shows participants doing a two-hour driving simulation had fewer incidents after combining caffeine and a nap compared to those who just had caffeine alone.

Jump in a cold shower to give yourself an energizing buzz. Cold water can increase your heart rate , metabolism, and blood pressure, making you feel more awake. It could even have an anti-depressive effect.

Not brave enough for a cold shower? Try splashing your face with cold water, instead. If you need a quick and easy pick-me-up, grab a glass of water.

Research shows even mild dehydration can make you feel tired, and the very act of drinking water can make you feel more alert.

Research shows listening to music can increase your energy levels, while sitting in silence or listening to relaxation instructions can make you feel sleepy. The music worked even better when participants liked the song.

Eating too close to bedtime can cause digestive issues, make it harder to fall asleep, and cause you to wake up during the night. Aim to be finished with dinner two to three hours before bedtime to help you get better sleep.

RISE can give you an exact dinner time to aim for. You can learn more about what time you should stop eating before bed here.

Expert tip: You want your overall diet to be healthy and balanced to feel more energy day to day. Eat plenty of fruits, veggies, and complex carbs like oatmeal and brown rice for a steady source of energy. What you eat can also impact your sleep.

Research from shows an overall diet rich in fiber, fruits, vegetables, and anti-inflammatory nutrients is best for sleep. And overeating can make you feel sleepy. Stress and anxiety can easily keep you up at night. To help, start doing a relaxing bedtime routine in the hour or so before you go to bed.

RISE can guide you through relaxation exercises like progressive muscle relaxation. This can help you wind down for bed and drift off more quickly. Research from found diaphragmatic breathing, or deep breathing, helped those with sleep apnea feel less daytime sleepiness.

A study — co-authored by one of our science advisors Dr. Psychological sighing is also known as cyclic sighing and involves extended exhalations.

Morning sunlight can reset your circadian rhythm , waking you up for the day and setting you up to feel sleepy at bedtime. Aim to get out in natural light for at least 10 minutes as soon as you can each morning. As tempting as it can be to hit snooze once or twice — or several times — try to get up at the same time each day.

A study found hitting the snooze alarm makes sleep inertia last longer compared to using a single alarm. Plus, waking up at the same time will help to keep your circadian rhythm in check for long-term energy. Expert tip: If you need to sleep in to get more shut-eye, limit this to an hour or so to avoid disrupting your circadian rhythm too much.

You can learn the best way to sleep in here. Did you know the sound you wake up to can make a difference to how tired you feel in the morning? With the RISE phone alarm, you can choose from melodic sounds, your choice of music, or gentle Apple watch or phone vibrations.

We already know exercise can boost your energy, but doing some physical activity first thing can help to jumpstart your day. One study found just 30 seconds of exercise can help you shake off sleep inertia in the morning. And research shows 10 minutes of low-to-moderate intensity exercise can give you more energy than 50 milligrams of caffeine.

Discover more ways to wake up faster in the morning here. But a large lunch can make afternoon sleepiness worse. Research shows a heavy lunch can increase sleepiness and decrease performance on a simulated driving test compared to a light lunch.

Resist the urge to reach for a sugary snack to make you feel more awake. Aim to go to bed and wake up at roughly the same times each day — even on your days off. This will help you regulate your circadian rhythm, so you feel more awake during the day and sleepy come bedtime. Research shows those with a regular sleep pattern feel less sleepy than those without a regular sleep pattern — even when both groups get the same amount of sleep.

Our data shows RISE users with consistent sleep patterns have lower sleep debt than those with inconsistent sleep patterns.

And lower sleep debt will help you feel more awake during the day and make your afternoon dip in energy feel more manageable. One study looked at participants who spent five nights getting either eight hours in bed, four hours in bed, or four hours in bed and did three high-intensity interval exercise sessions during the five days.

Those who only got four hours of sleep had a reduced glucose tolerance and mitochondrial respiratory function the process of energy conversion in your cells. But these impairments were not seen in the group who got four hours of sleep but did the three exercise sessions.

Working out while sleep deprived can increase your risk of injury , so depending on how much sleep you got, you might want to stick to a gentle workout, like yoga or swimming.

Check out our guide on how to work out on no sleep here. Napping is a great way to lower your sleep debt to feel more awake in the long run, but it can also give you an energy boost that day. A minute power nap is enough to reduce sleepiness in sleep-deprived people, and research shows naps can improve your alertness, performance, and mood.

Naps can even be beneficial for those who are not sleep deprived. Good sleep hygiene will help you fall asleep faster and wake up less often in the night. Good sleep hygiene can also help you get more restful sleep , which can make you feel more awake. Research from found more light sleep and less time awake at night are linked to better sleep satisfaction.

And a study found how people feel about their sleep had a bigger impact on daytime fatigue than sleep duration. They can test you for health conditions or sleep disorders that could be to blame.

Try these simple strategies to enjoy better quality sleep. If you suspect you have insomnia, sleep apnea, or another sleep disorder, talk with your doctor.

Many sleep disorders can be managed through lifestyle changes or other treatments. This is a noninvasive ventilator that helps keep your airways open while you sleep. Healthy sleep habits can help you fall asleep, stay asleep, or enjoy better quality sleep.

For example, a consistent sleep schedule is important. Try to go to bed and wake up at the same times each day, even on weekends and holidays. Making your bedroom more sleep-appropriate and comfortable can also help. Take steps to keep it dark, cool, comfortable, and quiet, such as the following:.

Developing a pre- sleep routine can also help prepare your body and mind for sleep. This routine should include relaxing activities, such as:. Avoid loud noises, bright lights, glowing computer screens, and other stimulating things before bedtime.

Since stress often causes sleep deprivation , efforts to reduce stress are also important. For example, consider:. Prioritize self-care by eating a well-balanced diet, getting regular exercise, and making time for activities you enjoy.

A doctor can recommend next steps and strategies to improve your sleep. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available.

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Health Conditions Discover Plan Connect. Sleep and Wakefulness. Medically reviewed by Raj Dasgupta, MD — By Amber Erickson Gabbey — Updated on May 26, What are the benefits of sleep?

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