Anto-aging constituents, antioxidant, and enzyme inhibitory activities Liver protection by in-silico study of n anti-sging extract and Long-term athlete development oil of guava leaves. Share Wnti-aging Liver protection Anit-aging LinkedIn More. Editor information Editors and Affiliations Department of Microbiology, Bayelsa Medical University, Yenagoa, Bayelsa, Nigeria Sylvester Chibueze Izah Department of Sustainable Development, Appalachian State University, Boone, USA Matthew Chidozie Ogwu Government College, University of Faisalabad, Islamabad, Pakistan Muhammad Akram. Solubility: soluble in any proportion in water.

Citrus aurantium for anti-aging -

依據本發明，醫藥品可進一步包含有一被廣泛地使用於藥物製造技術之醫藥上可接受的載劑 pharmaceutically acceptable carrier 。例如，該醫藥上可接受的載劑可包含一或多種選自於下列的試劑：溶劑 solvent 、緩衝液 buffer 、乳化劑 emulsifier 、懸浮劑 suspending agent 、分解劑 decomposer 、崩解劑 disintegrating agent 、分散劑 dispersing agent 、黏結劑 binding agent 、賦形劑 excipient 、安定劑 stabilizing agent 、螯合劑 chelating agent 、稀釋劑 diluent 、膠凝劑 gelling agent 、防腐劑 preservative 、潤濕劑 wetting agent 、潤滑劑 lubricant 、吸收延遲劑 absorption delaying agent 、脂質體 liposome 以 及類似之物。有關這些試劑的選用與數量是落在熟習此項技術之人士的專業素養與例行技術範疇內。 According to the present invention, the medicine may further include a pharmaceutically acceptable carrier which is widely used in medicine manufacturing technology.

For example, the pharmaceutically acceptable carrier may include one or more reagents selected from the group consisting of solvents, buffers, emulsifiers, suspending agents, decomposers , disintegrating agent, dispersing agent, binding agent, excipient, stabilizing agent, chelating agent, diluent , Gelling agent, preservative, wetting agent, lubricant, absorption delaying agent, liposome And the like.

The selection and quantity of these reagents fall within the scope of professionalism and routine techniques of those who are familiar with this technique. 依據本發明，該醫藥上可接受的載劑包含有一選自於由下列所構成之群組中的溶劑：水、生理鹽水 normal saline 、磷酸鹽緩衝生理鹽水 phosphate buffered saline,PBS 、含有醇的水性溶液 aqueous solution containing alcohol 以及它們的組合。 According to the present invention, the pharmaceutically acceptable carrier includes a solvent selected from the group consisting of water, normal saline normal saline , phosphate buffered saline PBS , Aqueous solution containing alcohol and combinations thereof.

依據本發明，該醫藥品可以一選自於由下列所構成之群組中的非經腸道途徑 parenteral routes 來投藥：皮下注射 subcutaneous injection 、表皮內注射 intraepidermal injection 、皮內注射 intradermal injection 以及病灶內注射 intralesional injection 。 According to the present invention, the drug can be administered by a parenteral route selected from the group consisting of: subcutaneous injection, intraepidermal injection, intradermal injection Injection intradermal injection and intralesional injection intralesional injection.

依據本發明，醫藥品可利用熟習此技藝者所詳知的技術而被製造成一適合於局部地施用於皮膚上的外部製劑 external preparation ，這包括，但不限於：乳劑 emulsion 、凝膠 gel 、軟膏 ointment 、乳霜 cream 、貼片 patch 、擦劑 liniment 、粉末 powder 、氣溶膠 aerosol 、噴霧 spray 、乳液 lotion 、乳漿 serum 、糊劑 paste 、泡沫 foam 、滴劑 drop 、懸浮液 suspension 、油膏 salve 以及繃帶 bandage 。 According to the present invention, the medicine can be manufactured into an external preparation suitable for topical application to the skin by using techniques well known to those skilled in the art.

This includes, but is not limited to: emulsion, coagulation Gel, ointment, cream, patch, liniment, powder, aerosol, spray, lotion, milk Serum, paste, foam, drop, suspension, salve and bandage.

依據本發明，該外部製劑是藉由將本發明的醫藥品與一為熟習此項技藝者所詳知的基底 base 相混合而被製備。 According to the present invention, the external preparation is prepared by mixing the medicine of the present invention with a base well known to those skilled in the art. The selection and quantity of these additives fall within the scope of professionalism and routine techniques of those who are familiar with this technology.

依據本發明，保養品可進一步包含有一被廣泛地使用於保養品製造技術之可接受的佐劑 acceptable adjuvant 。例如，該可接受的佐劑可包含有一或多種選自於下列的試劑：溶劑、膠凝劑、活性劑、防腐劑、抗氧化劑、遮蔽劑 screening agent 、螯合劑、界面活性劑、染色試劑 coloring agent 、增稠劑 thickening agent 、填料 filler 、香料以及氣味吸收劑。有關這些試劑的選用與數量是落在熟習此項技術之人士的專業素養與例行技術範疇內。 According to the present invention, the skin care product may further include an acceptable adjuvant that is widely used in skin care product manufacturing technology.

For example, the acceptable adjuvant may contain one or more agents selected from the group consisting of solvents, gelling agents, active agents, preservatives, antioxidants, screening agents, chelating agents, surfactants, dyes Coloring agent, thickening agent, filler, fragrance and odor absorber.

依據本發明，保養品可利用熟習此技藝者所詳知的技術而被製造成一適合於護膚 skincare 或化妝 makeup 的形式，這包括，但不限於：水性溶液 aqueous solution 、水-醇溶液 aqueous-alcohol solution 或油性溶液 oily solution 、呈水包油型 oil-in-watertype 、油包水型 water-in-oiltype 或複合型之乳劑、凝膠、軟膏、乳霜、面膜 mask 、貼片、貼布 pack 、擦劑、粉末、氣溶膠、噴霧、乳液、乳漿、糊劑、泡沫、分散液、滴劑、慕斯 mousse 、防曬油 sunblock 、化妝水 tonic water 、粉底 foundation 、卸妝產品 makeup remover products 、肥皂 soap 以及其他身體清潔產品 body cleansing products 等。 According to the present invention, the skin care product can be manufactured into a form suitable for skincare or makeup by using techniques well-known to those skilled in the art.

This includes, but is not limited to: aqueous solution aqueous solution , water -Alcohol solution aqueous-alcohol solution or oily solution oily solution , oil-in-water type, water-in-oil type or compound emulsion, gel, Ointment, cream, mask, patch, pack, liniment, powder, aerosol, spray, lotion, cream, paste, foam, dispersion, drops, mousse , Sunblock, tonic water, foundation, makeup remover products, soap, and other body cleansing products.

The selection and quantity of these topical agents fall within the scope of professionalism and routine techniques of those who are familiar with this technique.

依據本發明，食品產品可被當作食品添加物 food additive ，藉由習知方法於原料製備時添加，或是於食品的製作過程中添加，而與任一種可食性材料配製成供人類與非人類動物攝食的食品產品。 According to the present invention, a food product can be used as a food additive, which is added during the preparation of raw materials by a conventional method, or added during the preparation of food, and is formulated with any edible material for supply Food products consumed by humans and non-human animals.

依據本發明，食品產品的種類包括但不限於：飲料 beverages 、發酵食品 fermented foods 、烘培產品 bakery products 、健康食品 health foods 以及膳食補充品 dietary supplements 。 According to the present invention, the types of food products include, but are not limited to: beverages, fermented foods, bakery products, health foods, and dietary supplements.

本發明提供一種代代花萃取物用於製備減緩皮膚老化及減少細胞中脂肪含量之組合物的用途，本發明之代代花萃取物係以一溶劑萃取一代代花乾料所獲得，該溶劑為水、醇、或醇水混合物，其可用於減緩皮膚老化、以及減少細胞中脂肪的含量。 The present invention provides a use of a flower extract for preparing a composition for slowing skin aging and reducing the fat content in cells.

The flower extract of the present invention is obtained by extracting a dry material of the flower from the solvent. It is water, alcohol, or alcohol-water mixture, which can be used to slow down skin aging and reduce the fat content in cells.

同時，本發明用於製備減緩皮膚老化及減少細胞中脂肪含量之組合物，亦可包含一有效量之代代花萃取物及一醫藥上可接受之載體，該組合物係一醫藥品、一食品或一保養品。 At the same time, the present invention is used to prepare a composition for slowing down skin aging and reducing the fat content in cells. It can also include an effective amount of a flower extract and a pharmaceutically acceptable carrier.

The composition is a medicine, a Food or a skin care product. 以下將詳細說明本發明代代花萃取物之詳細萃取方法，與該代代花萃取物於抗糖化活性之測試、於抑制脂肪累積能力之測試、以及促進脂肪分解能力之測試，以證實該代代花萃取物對於減緩皮膚老化並達到皮膚美化的效果，以及減少細胞中脂肪的含量並達到減脂的效果。 The following will describe the detailed extraction method of the flower extract of the present invention, and the test of the anti-glycation activity of the flower extract, the test of the ability to inhibit fat accumulation, and the test of the ability to promote lipolysis to confirm the generation.

The flower extract has the effect of slowing down skin aging and beautifying the skin, as well as reducing the fat content in the cells and achieving the effect of reducing fat. After extraction, it was cooled to room temperature, and the crude extract was filtered through a mesh filter to obtain a filtrate.

Finally, the filtrate is concentrated under reduced pressure at °C to obtain the flower extract of the present invention. 本實施例係為了測試本發明之代代花萃取物的抗糖化活性，因此以抑制D-果糖 D-fructose 使膠原蛋白 Collagen 產生糖化的效率，進行糖化活性之定量。首先，分別取0. First, take 0.

Finally, the following formula is used to calculate the efficiency of the ability to eliminate advanced glycation end-products AGEs to represent its anti-glycation activity. The less the amount of glycation end-products, the higher the anti-glycation activity.

It inhibits non-enzymatic browning and avoids the denaturation of functional proteins in the body. This result shows that the daidaihua extract of the present invention can effectively improve its ability to remove the final glycation products , And help delay the progression of chronic diseases and aging, and studies have shown that glycation can cause deterioration of skin collagen, damage collagen fibers and elastic fibers, and cause wrinkles, sagging and even sallow dullness in the skin.

The invention of Daidaihua extract can also effectively slow down skin aging and achieve skin beautification effects. The mouse bone marrow stromal cell line was purchased from the American Type Culture Collection ATCC ® , numbered CRL TM.

為證實本發明之代代花萃取物具有抑制脂肪堆積的功效，首先將小鼠骨髓基質細胞分化成脂肪細胞，將8x10 4 個小鼠骨髓基質細胞培養於含有0. After 7 days, observe the formation of lipid droplets under a microscope to ensure that the cells are fully differentiated. Divide into 1 the experimental group with 0.

Value to quantify oil red O. This result shows that the daidaihua extract of the present invention can effectively inhibit fat accumulation and reduce the fat content in cells. 本實施例以上述小鼠骨髓基質細胞進行本發明之代代花萃取物於促進脂肪分解功效的測試。首先以實施例3之實驗步驟將小鼠骨髓基質細胞分化成脂肪細胞，同樣於開始培養7天後以顯微鏡觀察脂滴的形成，確保細胞已完全分化，接著將細胞分成 1 加入0.

First, the mouse bone marrow stromal cells were differentiated into adipocytes according to the experimental procedure of Example 3. The formation of lipid droplets was observed under a microscope 7 days after the start of culture to ensure that the cells were fully differentiated, and then the cells were divided into 1 and 0.

After the triglycerides stored in the cells are broken down, free glycerol and fatty acids are produced, so by measuring the extracellular Glycerin content can be used to infer the value of fat breakdown in cells.

This kit uses the measurement of the product content of the coupled enzyme reaction system that produces a bright purple product to quantify the value of extracellular glycerol, and establishes a standard curve with standard products to calculate the value of extracellular glycerol in the sample.

Collect the cell culture supernatant of each well, and transfer 25μL of the cell culture supernatant to a new well culture plate, and then add μL of reconstituted free glycerol assay reagent Free Glycerol Assay Reagent to each well React at room temperature for 15 minutes, and then read the value at OD nm.

This result shows that the daidaihua extract of the present invention can effectively promote lipolysis and reduce the fat content in cells. 綜上所述，本發明以水、醇類、或醇水混合物為溶劑所萃取得之代代花萃取物，能有效提升其清除糖化終產物之能力、有效抑制脂肪堆積、及有效促進脂肪分解，以減緩皮膚老化並達到皮膚美化的效果，以及減少細胞中脂肪的含量並達到減脂的效果。因此本發明之代代花萃取物可用於製備減緩皮 膚老化及減少細胞中脂肪含量之組合物的用途，該組合物該組合物是一醫藥品、一食品或一保養品，可藉由口服、皮膚塗抹等方式給予一個體。 To sum up, the present invention uses water, alcohol, or alcohol-water mixture as the solvent to extract the daidaihua extract, which can effectively improve its ability to remove the final glycation products, effectively inhibit fat accumulation, and effectively promote lipolysis , In order to slow down skin aging and achieve the effect of skin beautification, as well as reduce the fat content in the cell and achieve the effect of fat reduction.

Therefore, the flower extract of the present invention can be used to prepare skin The use of a composition for skin aging and reducing fat content in cells. The composition is a medicine, a food or a skin care product, which can be administered to a body by oral administration, skin application, etc.

The present invention provides a use of Citrus aurantium extract for reducing skin aging and fat content. The Citrus aurantium extract can improve the ability of removing advanced glycation end products AGEs , inhibit fat accumulation, and promote fat decomposition, so as to slow skin aging to improve the appearance of the skin, as well as to reduce the amount of fat in the cells to reduce the body fat.

The Citrus aurantium extract is prepared by extracting Citrus aurantium using water, alcohols, or mixtures of water and alcohols as solvents. 代代花萃取物用於減緩皮膚老化及減少細胞中脂肪含量的用途 The use of Daidaihua extract to slow down skin aging and reduce fat content in cells 本發明係關於一代代花萃取物之用途，尤其是一種代代花萃取物用於減緩皮膚老化及減少細胞中脂肪含量的用途。 The present invention relates to the use of Daidaihua extract, especially a use of Daidaihua extract to slow down skin aging and reduce the fat content in cells.

實施例2 本發明之代代花萃取物具有良好的抗糖化活性 Example 2 The Daidaihua extract of the present invention has good anti-glycation activity 本實施例係為了測試本發明之代代花萃取物的抗糖化活性，因此以抑制D-果糖 D-fructose 使膠原蛋白 Collagen 產生糖化的效率，進行糖化活性之定量。首先，分別取0. 一種代代花萃取物用於製備提升細胞抗糖化活性之組合物的用途，其中該代代花萃取物係以一溶劑萃取一代代花所獲得，該溶劑為水、醇、或醇水混合物。 A use of a flower generation extract for preparing a composition for enhancing the anti-glycation activity of cells, wherein the flower generation extract is obtained by extracting the first generation flower with a solvent, and the solvent is water, alcohol, or a mixture of alcohol and water.

如申請專利範圍第1項所述之用途，其中該代代花萃取物係具有皮膚抗老化及美肌之功效。 The use as described in item 1 of the scope of patent application, wherein the Daidaihua extract has the effects of anti-aging and beautifying skin. 一種代代花萃取物用於製備抑制細胞脂肪堆積之組合物的用途，其中該代代花萃取物係以一溶劑萃取一代代花所獲得，該溶劑為水、醇、或醇水混合物。 A use of a flower genus extract for preparing a composition for inhibiting cell fat accumulation, wherein the flower genus flower extract is obtained by extracting the flower genus flower with a solvent, and the solvent is water, alcohol, or a mixture of alcohol and water.

一種代代花萃取物用於製備促進細胞脂肪分解之組合物的用途，其中該代代花萃取物係以一溶劑萃取一代代花所獲得，該溶劑為水、醇、或醇水混合物。 The use of a flower genus extract for preparing a composition for promoting cell fat decomposition, wherein the flower genus flower extract is obtained by extracting the flower genus flower with a solvent, the solvent being water, alcohol, or a mixture of alcohol and water.

如申請專利範圍第4項或第6項所述之用途，其中該代代花萃取物係具有減少細胞脂肪之功效。 Such as the use described in item 4 or item 6 of the scope of patent application, wherein the flower extract has the effect of reducing cell fat. 如申請專利範圍第1項、第4項或第6項所述之用途，其中該代代花係一代代花乾料，且該溶劑與該代代花乾料之重量比為：。 For the purposes described in item 1, item 4 or item 6 of the scope of patent application, wherein the flower generation is a dry flower generation material, and the weight ratio of the solvent to the flower generation dry material is 如申請專利範圍第1項、第4項或第6項所述之用途，其中該組合物是一醫藥品、一食品或一保養品。 Such as the application described in item 1, item 4 or item 6 of the scope of patent application, wherein the composition is a medicine, a food or a skin care product.

TWA TWIB en. Application of seville orange flower extract in preparation of composition for improving anti-saccharification activity, inhibiting fat accumulation and promoting lipolysis.

TWA true TWA en. TWIB TWIB en. CNA en. It's also known as Citrus Sinensis. The oil is derived from the peel of this fruit, which is a rich source of various bioactive compounds and is widely utilized in the cosmetic industry.

Orange peel oil , notably from the species Citrus Aurantium Dulcis, is mainly composed of two essential components:. Other than these, orange peel oil is an excellent source of antioxidants which play a crucial role in protecting the skin from oxidative stress. Our formulation uses Citrus Aurantium Dulcis Oil for its natural, vegan essence, harnessing its capabilities to refresh and potentially help the skin's barrier against environmental aggressors.

We find that Citrus Aurantium Dulcis orange peel oil, also known as orange peel oil, is a valuable addition to skincare routines.

Its rich composition provides antioxidants and improves skin texture, while aiding in anti-aging treatments. Orange peel oil is abundant in Vitamin C— a potent antioxidant.

Antioxidants help protect the skin from environmental stressors, potentially reducing the risk of premature aging. By incorporating orange peel oil in our daily skincare, we harness these antioxidant benefits , promoting a radiant and healthier complexion.

We often seek ways to enhance the texture of our skin and orange peel oil can be a beneficial ingredient. Its properties may help in moisturizing the skin and refining pores, leading to a smoother appearance. Incorporating this oil into moisturizers or serums, we support the skin's natural clarity and texture.

Orange peel oil is known for its contribution to antiaging skin treatments. We recognize its role in minimizing the appearance of fine lines and wrinkles, attributes often sought after in antiaging products.

Through the use of essential oils like orange peel oil in our treatment regimens, we aim to maintain a youthful and firm skin tone. We recognize that while Citrus Aurantium Dulcis Orange Peel Oil is valued for its fragrant properties and potential skin benefits, understanding its safety and allergenic potential is crucial for informed use in skincare.

When it comes to Citrus Aurantium Dulcis Peel Oil, skin irritation can occur, particularly if you have sensitive skin. Irritation may manifest as redness, itching, or discomfort. As with many essential oils, the allergenic potential of this oil should not be underestimated; case studies have reported instances of allergic reactions.

Notably, Citrus Aurantium Dulcis Peel Oil is not listed among the 26 established cosmetic allergens. For Citrus Aurantium Dulcis Peel Oil, the concentration used in cosmetic products is significant. This threshold helps to balance efficacy with safety, ensuring the oil's benefits can be enjoyed without undue adverse effects.

We recognize Citrus Aurantium Dulcis Peel Oil, commonly known as sweet orange oil, as a valuable ingredient in skincare formulations. Its appealing fragrance and potential skincare benefits make it popular in a variety of cosmetic products. In our experience, incorporating sweet orange oil in skincare products requires careful consideration of its concentration and compatibility with other ingredients.

It functions primarily as a skin-conditioning agent and fragrance, where it imparts a refreshingly sweet citrus scent. Here's a simple guideline table on the use of orange oil in skincare formulations:. Orange oil is versatile and can be found across our skincare range. Specifically, we include it in:.

Through careful formulation, orange oil becomes a multi-faceted contributor to skincare products, offering both functional and sensory benefits. In comparing Citrus Aurantium Dulcis Orange Peel Oil with other fragrance options, we focus on how it differentiates from synthetic fragrances and other essential oils.

Citrus Aurantium Dulcis Peel Oil, as a natural ingredient, offers a scent derived from the actual peel of oranges. This stands in contrast to synthetic fragrances, which are created through chemical processes. While both can provide a lasting aroma, natural orange oils are also valued for potential skin benefits and are typically preferred in vegan formulations.

When we compare Citrus Aurantium Dulcis Oil to other essential oils, it's important to note its unique profile. Unlike some essential oils which can be more abrasive, orange peel oil is known for its gentle properties on the skin. This aspect makes it particularly suitable for inclusion in skin care products aimed at soothing the skin.

Moreover, the citrus scent offers a fresh and invigorating experience which often cannot be matched by other essential oils. In this section, we'll address common inquiries about the use of Citrus aurantium dulcis peel oil in skincare. Citrus aurantium dulcis peel oil is known for its skin conditioning properties.

It's also used for its fragrance and potential to brighten the skin. While both oils come from orange peels, Citrus aurantium dulcis peel oil is generally used at lower concentrations in skin care.

This may be due to its higher potency compared to Citrus sinensis peel oil. Yes, Citrus aurantium dulcis peel oil can help improve the skin's appearance by offering emollient properties and contributing to a brighter complexion.

Citrus aurantium dulcis peel oil has a lower maximum use concentration range in formulations, which suggests it is less likely to clog pores when used in recommended amounts.

Citrus aurantium dulcis peel oil is primarily used for skin conditioning, while oils like Citrus limon lemon may be more astringent. Citrus grandis grapefruit peel oil is often utilized for its refreshing scent and antioxidant properties. For best results, Citrus aurantium dulcis peel oil should be applied as part of a formulation and at concentrations advised by skin care professionals to ensure effective and safe usage.

Just added to your cart.

Hélène LESUR : Citrrus in flr to contact the contributor. Citrus aurantium for anti-aging EN Liver protection FR. Sign in. Search Loading Author Author Ctrus Author multi-criteria Author: Full name Author: Last name Author: First name Author: middle name Author: funding institution Author: IdHal string Author: function Author: personID integer Author: funding institution identifier Author: Structure identifier Thesis director Publisher Scientific editor Series editor Add. Aurrantium by cold compression from the peels of Citrus aurantium for anti-aging oranges, orange Citrus aurantium for anti-aging oil has anti-agibg antioxidant and antibacterial properties. It is also rich in flavonoids Anti-wging well as vitamins A and C. Allergy relief products Fermented foods for lactose intolerance medicine, ani-aging peel oil has been used to treat digestive and circulatory problems, and is widely acknowledged for its ability to breakdown fat, and is therefore commonly used in weight loss products. However, its above mentioned properties combined with antiseptic and detoxifying qualities also make this oil an excellent ingredient for skin conditioning, toning, and anti-aging formulations. Containing Alpha Pinene, Citronellal, Geranial, Sabinene, Myrcene, Limonene, Linalool and Neral, orange peel oil is an effective anti-inflammatory that works to soothe, detoxify and tone the skin.