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Oxidative stress and cancer

oxidative stress and cancer

Lon also participates in cysteine Role of Polyphenols in disease prevention to repress lipid peroxidative oxidatlve regulating ferroptosis [ 85 ]. EVIDENCE THAT REACTIVE SPECIES ARE IMPORTANT IN CANCER. search Search by keyword or author Search. com Biochemical Society Company no. Effects of nitro-oxidative stress on biomolecules: part 1-non-reactive molecular dynamics simulations. Luo, M.

Oxidative stress and cancer -

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Storz P Mitochondrial ROS—radical detoxification, mediated by protein kinase D. Trends Cell Biol 17 1 — Storz P Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal 14 4 — Storz P, Toker A Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway.

EMBO J 22 1 — Storz P, Doppler H, Toker A a Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol 24 7 — Storz P, Doppler H, Toker A b Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB.

Mol Pharmacol 66 4 — Storz P, Doppler H, Toker A a Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Mol Cell Biol 25 19 — Storz P et al b Functional dichotomy of A20 in apoptotic and necrotic cell death.

Biochem J Pt 1 — Storz P et al FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.

Mol Cell Biol 29 18 — Sun G, Kemble DJ To C or not to C: direct and indirect redox regulation of Src protein tyrosine kinase.

Cell Cycle 8 15 — Sundaresan M et al Requirement for generation of H 2 O 2 for platelet-derived growth factor signal transduction. Sundaresan M et al Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.

Szatrowski TP, Nathan CF Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res 51 3 — Takeda K et al Roles of MAPKKK ASK1 in stress-induced cell death. Cell Struct Funct 28 1 — Tanno T, Matsui W Development and maintenance of cancer stem cells under chronic inflammation.

J Nippon Med Sch 78 3 — Tiku ML, Liesch JB, Robertson FM Production of hydrogen peroxide by rabbit articular chondrocytes. Enhancement by cytokines. J Immunol 2 — Tobar N et al RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFkappaB-dependent mechanism.

Cancer Lett 1 — Tothova Z et al FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2 — Townsend DM, Tew KD The role of glutathione-S-transferase in anti-cancer drug resistance.

Oncogene 22 47 — Trachootham D et al Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 10 3 — Trachootham D, Alexandre J, Huang P Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

Nat Rev Drug Discov 8 7 — van Wetering S et al Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells. J Cell Sci Pt 9 — Wang M et al Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor.

Oncogene 24 55 — Wang Y et al The endogenous reactive oxygen species promote NF-kappaB activation by targeting on activation of NF-kappaB-inducing kinase in oral squamous carcinoma cells. Free Radic Res 41 9 — Ward JF Biochemistry of DNA lesions. Radiat Res Suppl 8:S—S Wells-Knecht MC et al Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes.

Evidence against a generalized increase in oxidative stress in diabetes. J Clin Invest 4 — Wenk J et al Stable overexpression of manganese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxidant in the APmediated induction of matrix-degrading metalloprotease J Biol Chem 36 — Werner E, Werb Z Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases.

J Cell Biol 2 — Wiseman H, Halliwell B Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Wood ZA et al Structure, mechanism and regulation of peroxiredoxins.

Trends Biochem Sci 28 1 — Wu WS The signaling mechanism of ROS in tumor progression. Cancer Metastasis Rev 25 4 — Xia C et al Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor.

Cancer Res 67 22 — Xin M, Deng X Nicotine inactivation of the proapoptotic function of Bax through phosphorylation.

J Biol Chem 11 — Xu YC et al Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. J Biol Chem 31 — Cell Cycle 5 6 — Yoeli-Lerner M et al Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 20 4 — Zhang R et al In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway.

Apoptosis 13 12 — Download references. The author would like to thank Heike Döppler and Jenni Bachhofer for critical reading of the manuscript. Work in the Storz laboratory is supported by the NIH grants GM and CA Department of Cancer Biology, Mayo Clinic, San Pablo Road, Jacksonville, FL, , USA.

You can also search for this author in PubMed Google Scholar. Correspondence to Peter Storz. and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA. The Alexander Silberman Institute of Life Science, Department of Biological Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel.

Reprints and permissions. Storz, P. Oxidative Stress in Cancer. In: Jakob, U. eds Oxidative Stress and Redox Regulation. Springer, Dordrecht. Published : 14 February Publisher Name : Springer, Dordrecht.

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Skip to main content. Abstract Increased oxidative stress is a common feature observed in many different types of cancer. Keywords Oxidative stress Reactive oxygen species Antioxidants Tumor Cancer. Buying options Chapter EUR eBook EUR Softcover Book EUR Hardcover Book EUR Tax calculation will be finalised at checkout Purchases are for personal use only Learn about institutional subscriptions.

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Sci STKE :re3 PubMed Google Scholar Storz P Mitochondrial ROS—radical detoxification, mediated by protein kinase D. Trends Cell Biol 17 1 —18 CAS PubMed Google Scholar Storz P Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxid Redox Signal 14 4 — CAS PubMed Google Scholar Storz P, Toker A Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway.

EMBO J 22 1 — CAS PubMed Google Scholar Storz P, Doppler H, Toker A a Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol 24 7 — CAS PubMed Central PubMed Google Scholar Storz P, Doppler H, Toker A b Activation loop phosphorylation controls protein kinase D-dependent activation of nuclear factor kappaB.

Mol Pharmacol 66 4 — CAS PubMed Google Scholar Storz P, Doppler H, Toker A a Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species.

Mol Cell Biol 25 19 — CAS PubMed Central PubMed Google Scholar Storz P et al b Functional dichotomy of A20 in apoptotic and necrotic cell death. Biochem J Pt 1 —55 CAS PubMed Google Scholar Storz P et al FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.

Mol Cell Biol 29 18 — CAS PubMed Central PubMed Google Scholar Sun G, Kemble DJ To C or not to C: direct and indirect redox regulation of Src protein tyrosine kinase. Cell Cycle 8 15 — CAS PubMed Google Scholar Sundaresan M et al Requirement for generation of H 2 O 2 for platelet-derived growth factor signal transduction.

Science — CAS PubMed Google Scholar Sundaresan M et al Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem J Pt 2 — CAS PubMed Google Scholar Szatrowski TP, Nathan CF Production of large amounts of hydrogen peroxide by human tumor cells.

Cancer Res 51 3 — CAS PubMed Google Scholar Takeda K et al Roles of MAPKKK ASK1 in stress-induced cell death. Cell Struct Funct 28 1 —29 CAS PubMed Google Scholar Tanno T, Matsui W Development and maintenance of cancer stem cells under chronic inflammation.

J Nippon Med Sch 78 3 — CAS PubMed Central PubMed Google Scholar Tiku ML, Liesch JB, Robertson FM Production of hydrogen peroxide by rabbit articular chondrocytes. J Immunol 2 — CAS PubMed Google Scholar Tobar N et al RAC1 activity and intracellular ROS modulate the migratory potential of MCF-7 cells through a NADPH oxidase and NFkappaB-dependent mechanism.

Cancer Lett 1 — CAS PubMed Google Scholar Tothova Z et al FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.

Cell 2 — CAS PubMed Google Scholar Townsend DM, Tew KD The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 22 47 — CAS PubMed Google Scholar Trachootham D et al Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

Cancer Cell 10 3 — CAS PubMed Google Scholar Trachootham D, Alexandre J, Huang P Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8 7 — CAS PubMed Google Scholar van Wetering S et al Reactive oxygen species mediate Rac-induced loss of cell-cell adhesion in primary human endothelial cells.

J Cell Sci Pt 9 — PubMed Google Scholar Wang M et al Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Oncogene 24 55 — CAS PubMed Google Scholar Wang Y et al The endogenous reactive oxygen species promote NF-kappaB activation by targeting on activation of NF-kappaB-inducing kinase in oral squamous carcinoma cells.

Free Radic Res 41 9 — CAS PubMed Google Scholar Ward JF Biochemistry of DNA lesions. Radiat Res Suppl 8:S—S CAS PubMed Google Scholar Wells-Knecht MC et al Age-dependent increase in ortho-tyrosine and methionine sulfoxide in human skin collagen is not accelerated in diabetes.

J Clin Invest 4 — CAS PubMed Central PubMed Google Scholar Wenk J et al Stable overexpression of manganese superoxide dismutase in mitochondria identifies hydrogen peroxide as a major oxidant in the APmediated induction of matrix-degrading metalloprotease J Biol Chem 36 — CAS PubMed Google Scholar Werner E, Werb Z Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases.

J Cell Biol 2 — CAS PubMed Google Scholar Wiseman H, Halliwell B Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer.

Biochem J Pt 1 —29 CAS PubMed Google Scholar Wood ZA et al Structure, mechanism and regulation of peroxiredoxins. Trends Biochem Sci 28 1 —40 CAS PubMed Google Scholar Wu WS The signaling mechanism of ROS in tumor progression.

Cancer Metastasis Rev 25 4 — CAS PubMed Google Scholar Xia C et al Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor. Cancer Res 67 22 — CAS PubMed Google Scholar Xin M, Deng X Nicotine inactivation of the proapoptotic function of Bax through phosphorylation.

J Biol Chem 11 — CAS PubMed Google Scholar Xu YC et al Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. Cell Cycle 5 6 — PubMed Google Scholar Yoeli-Lerner M et al Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT.

Mol Cell 20 4 — CAS PubMed Google Scholar Zhang R et al In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis 13 12 — CAS PubMed Google Scholar Download references.

Acknowledgements The author would like to thank Heike Döppler and Jenni Bachhofer for critical reading of the manuscript.

Editor-in-Chief: Alessandro Antonelli Department of Clinical and Experimental Medicine Laboratory of Primary Human Cells Role of Polyphenols in disease prevention of Pisa Pisa Oxidatice. ISSN Print : Ocidative Online Freshly prepared meals Ccancer Background: Cancer is Pre-game meal options a major cause of death worldwide. The etiology of cancer is linked to environmental and genetic inheritance causes. Approximately 90 percent of all human cancers have an environmental cause non-genetic inheritance predominantly through lifestyle choices smoking, diet, UV radiation while the remaining due to infections and chemical exposure. Cancer is a multistage process that involves mutational changes and uncontrolled cell proliferation. Thank dtress for visiting nature. You are using a Role of Polyphenols in disease prevention version with limited stdess for CSS. To obtain Freshly prepared meals best experience, we tsress you use a Qnd up to date browser or turn off stresz mode in Internet Explorer. In the meantime, to Metabolic syndrome prevention continued support, we are displaying the site without styles and JavaScript. Reactive oxygen species ROS constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. It is now well accepted that moderate levels of ROS are required for several cellular functions, including gene expression. The production of ROS is elevated in tumor cells as a consequence of increased metabolic rate, gene mutation and relative hypoxia, and excess ROS are quenched by increased antioxidant enzymatic and nonenzymatic pathways in the same cells. oxidative stress and cancer

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