Category: Diet

Powerful weight loss supplements

Powerful weight loss supplements

Some safety Ppwerful reported, especially for combinations Powerful weight loss supplements other stimulants Reported adverse Powerrul : Chest pain, anxiety, headache, musculoskeletal complaints, and increased blood pressure and heart rate. Spatz3 Adjustable Gastric Balloon. Show references Dietary supplements for weight loss.

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17 Supplements that are Actually Worth Taking for Fat Loss and More

Home Powercul Nutrition » Weight Management weibht Best Weight Loss Supplements. We believe information wdight products suppplements services that could benefit Suppleemnts should be made Powerfyl to koss to help them make informed decisions about their health care.

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Content is fact-checked after Losa has been edited and before sulplements. Each article is created without any suoplements influence. When you use our provided links to buy products, we su;plements a commission as an affiliate. To understand supppements we generate supplemejts, please read supplemments advertising disclaimer.

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Check Price. See PhenQ Ssupplements. PhenQ is a very reputable and reliable dietary supplement. Energizing essential oils Enhance insulin sensitivity and promote longevity includes five Enhance insulin sensitivity and promote longevity effects: it burns fatblocks the production of further fat Ppwerful body weight, suppresses appetite, increases energy levels, and improves your mood.

Their brand is well wekght and has few reported supplemwnts of zupplements effects or contamination. Gluten-free meal choices ingredients are reliable and spuplements backed. Weibht should take two pills per eeight, one with breakfast Powerfull one Glutathione capsules lunch.

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See LeanBean Reviews. LeanBean is fantastic xupplements any suupplements of sensitivity. It has no caffeine at all, which is Dark chocolate love massive win for people with caffeine sensitivities. With their money-back guarantee, suupplements can try it Powrrful a while before Obesity and long-term effects commit although some people suppements said the return process is difficult and confusing.

You have to take weught large number wdight the capsules — Poweful each Recommended supplements for athletes breakfast, lunch, and dinner, Enhance insulin sensitivity and promote longevity, for six total in a day.

See Instant Knockout Reviews. Instant Knockout is a serious, powerful, effective weight loss supplement. The high concentrations of caffeine are better for men than for womenalthough women can also use it.

The ingredients are all-natural, and it works very well as an appetite suppressant and a metabolism booster. One of the best features of Instant Knockout is its transparency. There are no proprietary blends or secret ingredients.

The fist-shaped bottle is just a fun bonus! Be careful not to eat supper too late in the evening, or the caffeine might interfere with your sleep. See PhenGold Reviews. PhenGold contains no synthetic materials; all ingredients are natural. It has several effects; it helps promote weight loss, encourages fat burningand speeds up the metabolism.

There are no proprietary ingredients, so you can understand what each ingredient does. It contains a fair amount of caffeine, but not as large a dose as some of the others.

PhenGold is soy-free, gluten-free, dairy-free, vegan, and non-GMO. See PrimeShed Reviews. PrimeShred advertises three significant effects: increasing fat-burning thermogenesis[1] speeding up metabolism, and maintaining energy and focus.

It contains high-quality natural ingredients, and every ingredient is transparently listed on the label. See Phen24 Reviews. This twenty-four-hour system includes two different pills, one for the morning and one for the evening.

The daytime pill, for example, increases metabolism and energy while decreasing appetite, while the nighttime pill decreases food cravings and cortisol levels to help with weight management and better sleep. The ingredients are clean and transparent and include vitamins and minerals to enhance your overall health in addition to the weight loss features.

See TrimTone Reviews. TrimTone is the simplest pill on this list. It works through appetite suppression, fat burning, and increasing energy and focus. However, it has a large amount of caffeine and other stimulants, which women can be more sensitive to than men.

Since every person reacts differently to various compounds, the best way to choose pills is to try them and see what works. Green tea extract [2] boosts thermogenesis, especially when combined with exercise and other parts of a healthy lifestyle. In addition, it improves glucose tolerance [3] and helps oxidize fat.

Studies have shown that caffeine can help you lose weight[4] but mostly when accompanied by a healthy diet and exercise. It aids in speeding up your metabolism, making exercise more effective.

This is a difficult-to-pronounce ingredient derived from plants that have been cultivated for medicine in China for a long time.

There are prescription weight loss drugs[5] which are often more effective than the over-the-counter version if your physician agrees you should use them.

The alternative natural weight loss pills can be better if you want organic compounds and try to avoid synthesized chemicals as in prescription medications. Whether you choose prescription weight loss drugs or not is up to you and your preference.

Always take the recommended dose. This is a difficult question to answer since it varies depending on the brand and the ingredients. There are a lot of different dietary supplements to help you lose weight on the market, but we hope this guide helps you select the best options for yourself and your lifestyle!

All three are alternatives to the brand Phentermine, a prescription weight loss medication. You should definitely not do that! These pills are designed to work alone, and most of them use the same ingredients so that you could get much too high a dose. Keep an eye out for adverse effects.

Stop taking the supplements or find a different brand if you need to. EHproject has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We work mostly with peer-reviewed studies to ensure accurate information. We avoid using tertiary references.

You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Christine is a certified personal trainer and nutritionist with an undergraduate degree from Missouri State University. Her passion is helping others learn how strong and healthy they can become by transforming their daily habits.

Christine spends… See More. Expert's opinion We believe information about products and services that could benefit people should be made available to consumers to help them make informed decisions about their health care.

Check Price See PhenQ Reviews. Vegan Good money-back guarantee Few side effects No synthetic additives Free shipping globally Not suitable for children or pregnant or nursing mothers Has a large amount of caffeine. Check Price See LeanBean Reviews.

Formulated for women Caffeine-free Vegan, gluten-free, soy-free, non-GMO, and organic Testing results are available online day money-back guarantee Complicated return policy Six pills each day Results can be delayed and may vary.

Instant Knockout. Check Price See Instant Knockout Reviews. Check Price See PhenGold Reviews. Good money-back guarantee FDA registered facility Fast and reliable shipping No proprietary, secret ingredients High concentration of caffeine Can be expensive The availability is limited to certain countries.

Check Price See PrimeShed Reviews. Lose excess weight without losing muscle Backed by clinical research Naturally grown, soy-free, gluten-free, non-GMO, and vegan Sometimes causes upset stomachs Can be expensive Not safe for pregnant or breastfeeding women.

Check Price See Phen24 Reviews. Check Price See TrimTone Reviews. Made for women Suppresses the appetite Only one pill a day Not vegan Not safe for pregnant or breastfeeding women High levels of stimulants such as caffeine. Frequently Asked Questions FAQs. Are PhenQ, PhenGold, and Phen24 related?

Can you take more than one weight loss supplement? My weight loss supplements are making me feel sick?

: Powerful weight loss supplements

The Best Vitamins for Weight Loss: A Comprehensive Guide

So it's impossible to tell which ingredient was responsible for the weight loss. Ideally these initial results would be tested in a much longer trial involving hundreds of participants with careful monitoring for side effects.

Results from such a trial would allow for an informed decision about the safety and effectiveness of such a product. Until such trial data is more readily available, claims regarding dietary supplements and weight loss should be treated with caution. A product isn't necessarily safe simply because it's natural.

Though rare, some dietary supplements have been linked to serious problems, such as liver damage. Supplements can have strong effects. Ephedra ma-huang is an herb once used for weight loss.

It's now banned by the FDA because it was associated with adverse effects, such as mood changes, high blood pressure, irregular heart rate, stroke, seizures and heart attacks. Some weight-loss supplements have been found to contain hidden ingredients, such as prescription drugs, that may be harmful.

It's important to do your homework if you're thinking about trying a weight-loss supplement. Check credible websites, such as those run by the U.

Office of Dietary Supplements and the National Center for Complementary and Integrative Health. Also be sure to talk with your doctor before taking any supplement. This is especially important if you have health problems, take prescription drugs, or are pregnant or breast-feeding.

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Products and services. Dietary supplements for weight loss Melt away fat. Lose weight naturally. Tempting claims, but do the products deliver? By Mayo Clinic Staff. Thank you for subscribing! Sorry something went wrong with your subscription Please, try again in a couple of minutes Retry.

Show references Dietary supplements for weight loss. Office of Dietary Supplements. Accessed Oct. Perreault L. Obesity in adults: Drug therapy. Dietary supplements. Food and Drug Administration. Barrea L, et al. Nutritionist and obesity: Brief overview on efficacy, safety, and drug interactions of the main weight-loss dietary supplements.

International Journal of Obesity Supplements. Bray GA, et al. The science of obesity management: An Endocrine Society scientific statement. Endocrinology Review. Raynor HA, et al. Position of the Academy of Nutrition and Dietetics: Interventions for the treatment of overweight and obesity in adults.

Journal of the Academy of Nutrition and Dietetics. Esteghamati A, et al. Complementary and alternative medicine for the treatment of obesity: A critical review.

International Journal of Endocrinology and Metabolism. Using dietary supplements wisely. National Center for Complementary and Integrative Health. It might also reduce fat and protein absorption in the gut [ 16 ].

Glucomannan appears to have beneficial effects on blood lipids and glucose levels [ ], but its effects on weight loss are inconsistent. At the end of the study, glucomannan produced significantly greater weight loss mean loss of 2. In another study conducted in the United States, supplementation with glucomannan 3.

Eight weeks of glucomannan supplementation 1. The authors of a systematic review of six randomized controlled trials with a total of participants concluded that 1. Similarly, a meta-analysis of eight trials that included participants found that glucomannan did not significantly affect weight loss compared to placebo [ ].

The authors of an older meta-analysis of 14 studies designed primarily to investigate glucomannan's effect on lipid and blood glucose levels concluded that 1. Little is known about the long-term safety of glucomannan. Glucomannan appears to be well tolerated for short-term use, with minor adverse effects, including belching, bloating, loose stools, flatulence, diarrhea, constipation, and abdominal discomfort [ , , , ].

The use of tablet forms of glucomannan was reported to be associated with seven cases of esophageal obstruction in — in Australia [ 99 ]. Users should therefore be cautious when taking glucomannan tablets. Powdered and capsule forms have not been associated with this effect [ ].

The seeds or beans of the coffee plant Coffea arabica, Coffea canephora, Coffea robusta are green until they are roasted. Compared to roasted beans, green coffee beans have higher levels of chlorogenic acid.

Green coffee extract, probably because of its chlorogenic acid content, inhibits fat accumulation in mice and humans by regulating adipogenesis. Green coffee extract also modulates glucose metabolism [ ], perhaps by reducing glucose absorption in the gut [ ].

Green coffee beans contain caffeine see section on caffeine above [ ], although decaffeinated forms are available [ 16 ]. In mice, green coffee bean extract in combination with a high-fat diet significantly reduced body weight gain and fat mass [ , ].

Only a few clinical trials have examined the effects of green coffee bean extract on weight loss in humans, and all were of poor methodological quality. The researchers concluded that green coffee bean extract has a moderate but significant effect on body weight mean weight loss of 2.

The authors of another small clinical trial claimed to show a benefit of green coffee bean extract for weight loss [ ], but the study was strongly criticized by the FTC for having several critical flaws in its design [ , ].

Two of the three study authors subsequently retracted the journal publication. Green coffee bean extract appears to be well tolerated, but its safety has not been rigorously studied.

Reported adverse effects include headaches and urinary tract infections [ ]. The caffeine naturally present in green coffee beans acts as a stimulant and can cause adverse effects, depending on the dose and whether it is combined with other stimulants see section on caffeine above.

Green tea Camellia sinensis is a popular beverage consumed worldwide that has several purported health benefits [ ]. Green tea is present in some dietary supplements, frequently in the form of green tea extract. The active components of green tea that are associated with weight loss are caffeine see section on caffeine above and catechins, primarily epigallocatechin gallate EGCG , which is a flavonoid [ 41 , ].

A typical brewed cup of green tea has about — mg catechins [ ] and 45 mg caffeine. It has been suggested that green tea and its components might reduce body weight by increasing energy expenditure and fat oxidation, reducing lipogenesis, and decreasing fat absorption [ 41 , ].

Green tea might also decrease carbohydrate digestion and absorption [ ]. Available green tea extracts cover the range from minimally processed tea leaves to highly processed, manufactured concentrates of single constituents, such as EGCG.

The authors of a meta-analysis of six randomized controlled trials with a total of 98 participants found that caffeine alone or in combination with catechins significantly increases energy expenditure in a dose-dependent fashion compared with placebo [ ].

This effect might be important for maintaining weight loss by helping counteract the decrease in metabolic rate that can occur during weight loss. Catechins combined with caffeine also significantly increase fat oxidation, but caffeine alone does not.

Other human research indicates that EGCG alone does not increase resting metabolic rate, fat oxidation, or the thermic effect of feeding the increase in metabolic rate associated with the digestion and absorption of food [ , ]. Taken together, these findings suggest that green tea catechins and caffeine might act synergistically [ 41 , , ].

Several human studies have examined the effects of green tea catechins on weight loss and weight maintenance. A Cochrane Review analyzed the results from 14 randomized controlled trials of green tea preparations in a total of 1, participants with overweight or obesity [ ]. The trials lasted from 12 to 13 weeks, and doses of green tea catechins ranged from to 1, mg; in 10 of the 14 trials, the green tea preparations contained caffeine.

Green tea supplementation reduced body weight by a mean of 0. However, when the authors analyzed the six studies that were conducted outside of Japan where study methodologies were less heterogeneous than in the Japanese studies , they found no statistically significant difference in weight loss for green tea compared to placebo.

The authors reported that green tea catechins combined with caffeine over a median of 12 weeks modestly yet significantly reduced body weight by a mean of 1.

Only two studies in this meta-analysis examined the effects of green tea catechins alone. Their results suggest that green tea catechins alone do not affect body weight or other anthropometric measurements.

A meta-analysis of 11 randomized controlled trials found that people who took EGCG combined with caffeine for 12—13 weeks lost a mean of 1. In , EFSA examined health claims related to green tea and concluded that "a cause and effect relationship has not been established between the consumption of catechins including EGCG from green tea … and contribution to the maintenance or achievement of a normal body weight" [ ].

Taken together, the findings of these studies suggest that if green tea is an effective weight-loss aid, any effect it has is small and not likely to be clinically relevant [ , ]. No adverse effects have been reported from the consumption of green tea as a beverage [ ].

For green tea extract, most reported adverse effects are mild to moderate, and they include nausea, constipation, abdominal discomfort, and increased blood pressure [ ]. Toxicology studies in rats and mice show that green tea extract does not cause cancer but does cause nonneoplastic lesions in many areas of the body, including the nose, liver, and bone marrow [ ].

Other evidence in mice shows that high doses of catechins cause liver toxicity. There is also increasing evidence in humans that green tea extract might cause liver damage, though the underlying mechanism is not well understood [ ].

An analysis of 1, postmenopausal women participating in the Minnesota Green Tea Trial found that women who consumed green tea extract containing 1, mg total catechins including mg EGCG and Consumption of some green tea extracts—primarily ethanolic extracts of green tea—has also been linked to liver damage in at least 50 case reports since [ 43 , ].

In , the U. Pharmacopeia USP systematically reviewed the safety of green tea products [ ]. The USP noted that problems are more likely when green tea extract is taken on an empty stomach and, therefore, advises taking green tea extracts with food to minimize the possible risk of liver damage.

Other researchers and medical experts advise using dietary supplements containing green tea extract only with caution [ ]. Guar gum is a soluble dietary fiber derived from seeds of the Indian cluster bean Cyamopsis tetragonolobus [ 16 , ].

Guar gum is present in certain dietary supplements and is an ingredient in some food products, especially gluten-free baked goods, because it helps bind and thicken these products. Like glucomannan, guar gum is purported to promote weight loss by acting as a bulking agent in the gut; delaying gastric emptying; increasing feelings of satiety; and, theoretically, decreasing appetite and food intake [ 16 , ].

However, guar gum does not appear to enhance weight loss. In a meta-analysis of 20 randomized, double-blind, placebo-controlled trials that statistically pooled data from 11 trials, Pittler and colleagues evaluated the effects of guar gum for body weight reduction in a total of adults [ ].

Trial participants included people with hypercholesterolemia, hyperlipidemia, or type 1 or type 2 diabetes; menopausal women; and healthy volunteers.

Compared with placebo, guar gum had no significant effect on weight loss. The authors concluded that guar gum is not effective for body weight reduction. Reported adverse effects for guar gum are primarily gastrointestinal and include abdominal pain, flatulence, diarrhea, increased number of bowel movements, nausea, and cramps [ , , ].

Case reports indicate that guar gum can cause severe esophageal and small-bowel obstruction if taken without sufficient fluid [ , ]. However, these reports were about a guar gum product that is no longer available [ ].

In their meta-analysis, Pittler and colleagues concluded that given the adverse effects associated with the use of guar gum, the risks of taking it outweigh its benefits [ ]. Hoodia gordonii is a succulent plant that grows in the Kalahari Desert of southern Africa.

The San people have traditionally used hoodia as an appetite suppressant during long hunts. This anecdotal evidence, combined with results of a few animal studies indicating that hoodia reduces food intake [ ], led to the widespread marketing of hoodia as a weight-loss supplement in the United States in the early s.

Scientists have not determined the exact mechanism whereby hoodia might suppress appetite. A glycoside commonly called P57, which may have central nervous system activity [ ], is widely believed to be the main active ingredient, although not all researchers agree [ 16 , ].

Despite its popularity as a weight-loss supplement, very little scientific research on hoodia has been conducted in humans [ ]. Compared to placebo, hoodia extract had no significant effect on energy intake or body weight. Hoodia has been reported to cause significant increases in heart rate and blood pressure [ ].

It also raises bilirubin and alkaline phosphatase levels which may indicate impaired liver function , although the clinical significance of these findings is unclear because hoodia has not been reported to affect levels of other liver enzymes.

Other side effects include headache, dizziness, nausea, and vomiting. In the past, some hoodia products were found to contain little or no hoodia [ ]. The human microbiota, which outnumber human cells by up to fold, have myriad roles in human health [ , ]. Although microbes are found throughout the human body, the vast majority inhabit the colon.

The gut microbiota play an important role in nutrient and energy extraction from food. Research in mice suggests that the gut microbiota affect not only use of energy from the diet but also energy expenditure and storage within the host [ ].

Whether these effects translate to humans is unknown. However, manipulating the gut microbiota has been proposed as a method to prevent or treat obesity in humans, and probiotics might provide a way to accomplish this.

Probiotics are in foods, such as some yogurts, as well as dietary supplements. The many different genera of probiotics include Lactobacillus, Streptococcus, and Bifidobacterium, which all have widely varying effects in the body [ , ].

Much of the research on probiotics and its influence on the gut microbiota and obesity has been in mice, and the results have been promising. For example, probiotic supplementation reduced body weight gain and fat accumulation in obese mice fed a high-fat diet [ ]. In humans, however, results of clinical trials that assessed the impact of probiotics on obesity-related endpoints have been inconsistent.

In another randomized clinical trial, daily supplementation with 3. However, among the 77 female participants, the Lactobacillus supplementation did significantly reduce body weight after 12 weeks loss of 1.

Another recent systematic review and meta-analysis of 15 randomized controlled trials in individuals with overweight or obesity found that supplementation with various doses and strains of probiotics for 3 to 12 weeks resulted in larger reductions in body weight by 0.

However, these effects were small and of questionable clinical significance. The most recent systematic review and meta-analysis, which included 19 randomized trials in 1, participants, found that supplementation with probiotics or synbiotics products containing both probiotic organisms and prebiotic sugars, which microorganisms in the gastrointestinal tract use as metabolic fuel reduced waist circumference slightly by 0.

The findings from another meta-analysis of 14 trials in adults, 5 trials in children, and 12 trials in 1, infants suggested that probiotics promote an average loss of 0. Taken together, these results indicate that the effects of probiotics on body weight and obesity might depend on several factors, including the probiotic strain, dose, and duration as well as certain characteristics of the user, including age, sex, and baseline body weight.

Additional research is needed to understand the potential effects of probiotics on body fat, body weight, and obesity in humans. Many probiotic strains derive from species with a long history of safe use in foods or from microorganisms that colonize healthy gastrointestinal tracts.

For these reasons, the common probiotic species—such as Lactobacillus species acidophilus, casei, fermentum, gasseri, johnsonii, paracasei, plantarum, rhamnosus, and salivarius and Bifidobacterium species adolescentis, animalis, bifidum, breve, and longum —are unlikely to cause harm [ ].

Side effects of probiotics are usually minor and consist of self-limited gastrointestinal symptoms, such as gas. In a few cases, mainly involving individuals who were severely ill or immunocompromised, the use of probiotics has been linked to bacteremia, fungemia fungi in the blood , or infections that result in severe illness [ , ].

For individuals with compromised immune function or other serious underlying diseases, the World Gastroenterology Organisation advises restricting probiotic use to the strains and indications that have proven efficacy [ ].

Pyruvate is a three-carbon compound that is generated in the body through glycolysis [ ]. Pyruvate is also available as a dietary supplement, frequently in the form of calcium pyruvate. Researchers have suggested that pyruvate enhances exercise performance and reduces body weight and body fat, possibly by increasing lipolysis and energy expenditure [ 6 , , ].

Only a few studies have examined the effects of pyruvate supplementation in humans. Although some of these studies suggest that pyruvate decreases body weight and body fat, others do not.

At the end of the trial, the pyruvate group had significant decreases in body weight mean loss of 1. In the placebo group, these measurements did not change significantly compared to baseline.

However, a double-blind, placebo-controlled trial in 23 women who were overweight mean BMI The authors of a systematic review and meta-analysis of six randomized controlled trials in a total of participants concluded that 5—30 g pyruvate for 3—6 weeks reduces body weight by a mean of 0.

However, the authors noted that the methodological quality of all trials is weak, preventing them from drawing firm conclusions. The safety of pyruvate has not been rigorously studied.

Pyruvate might also increase LDL levels and decrease HDL levels [ , ]. Additional research is needed to better understand the safety and possible side effects of this compound.

Raspberry ketone is the primary aroma compound found in red raspberries Rubus idaeus , and it is added to some foods as a flavoring agent [ 16 , ].

In vitro and animal studies suggest that raspberry ketone might help prevent weight gain by increasing fatty acid oxidation, suppressing lipid accumulation, and inhibiting pancreatic lipase activity [ 16 ]. Although it has been touted on the Internet and national television as an effective way to burn fat, little evidence exists to support this claim.

In mice fed a high-fat diet, raspberry ketone supplementation reduced food intake and body weight compared to the same diet without raspberry ketone [ ].

Only one randomized controlled trial has examined the effects of a dietary supplement containing raspberry ketone on weight loss.

This product contained 2, mg of a proprietary blend of raspberry ketone, caffeine, bitter orange, ginger, garlic, cayenne, L-theanine, and pepper extract along with B-vitamins and chromium.

During the 8-week study, participants followed a calorie-restricted diet approximately calories less per day than estimated needs and engaged in moderate exercise 60 minutes 3 days per week. Compared to the placebo group, those receiving METABO lost significantly more body weight mean loss of 1.

However, 25 of the 70 participants dropped out of the study, and results were reported for only the 45 participants who completed the study i. Furthermore, the product contained many ingredients in addition to raspberry ketone, making it impossible to determine the effects of raspberry ketone alone.

Typical diets provide only a few mg of raspberry ketone a day. Doses contained in dietary supplements typically range from to 1, mg, and the safety of such doses has never been evaluated in humans [ ].

Participants in the METABO study described above had no serious adverse effects [ ]. However, additional research on raspberry ketone is needed to better understand its safety and side effects.

Vitamin D, which is fat soluble, is present in a few foods, such as fatty fish, cheese, egg yolks, and vitamin D-fortified milk. It is also available in many dietary supplements, and humans synthesize it naturally when their skin is exposed to sunlight.

Vitamin D promotes calcium absorption in the gastrointestinal tract and is needed for proper bone growth and remodeling [ 56 ].

Observational studies indicate that greater body weights are associated with lower vitamin D status, and individuals with obesity frequently have marginal or deficient circulating levels of vitamin D [ ]. Nevertheless, the association between vitamin D and obesity raises the question of whether increasing vitamin D concentrations might reduce body weight [ , ].

Despite the association between low vitamin D levels and obesity, scientific evidence does not support a cause-and-effect relationship. The authors commented that the cause of this finding might have been stored vitamin D in body fat and skeletal muscle that was released during weight loss.

However, according to a meta-analysis of 12 vitamin D supplementation trials including 5 in which body composition measurements were primary outcomes , vitamin D supplements without calorie restriction did not affect body weight or fat mass compared to placebo [ ].

Overall, the available research suggests that consuming higher amounts of vitamin D or taking vitamin D supplements does not promote weight loss.

Vitamin D toxicity can cause anorexia, weight loss, polyuria, and heart arrhythmias. It can also raise calcium blood levels, which can cause vascular and tissue calcification.

White kidney bean or bean pod Phaseolus vulgaris is a legume that is native to Mexico, Central America, and South America and is cultivated worldwide [ ]. Phaseolus vulgaris extract is an ingredient in some weight-loss dietary supplements marketed as carbohydrate- or starch-absorption blockers.

Laboratory research indicates that Phaseolus vulgaris extract inhibits alpha-amylase activity, so experts have hypothesized that the plant interferes with the breakdown and absorption of carbohydrates in the gastrointestinal tract [ 16 , ].

Phaseolus vulgaris might also act as an appetite suppressant [ , ]. The effect of Phaseolus vulgaris on weight loss and body fat has been examined in a few clinical trials, which had inconsistent results.

In a randomized, double-blind, placebo-controlled trial in Italy, 60 women who were mildly overweight mean BMI 26 and age 20—45 followed a 2,—2,calorie meal plan and took a tablet containing approximately mg dried aqueous extract of Phaseolus vulgaris Phase 2 Starch Neutralizer IV or a placebo once daily before eating a carbohydrate-rich meal [ ].

After 30 days, those receiving Phaseolus vulgaris extract lost significantly more weight mean weight loss 2. Those in the Phaseolus vulgaris group also experienced a significantly greater reduction in fat mass, adipose tissue thickness, and waist—hip—thigh circumference.

However, the authors noted that the quality of the trials included in their review was poor, making it impossible to draw firm conclusions. After the publication of that review, a week clinical trial in men and women with overweight or obesity BMI 25—35 showed that Phaseolus vulgaris modestly yet significantly reduced body weight and body fat [ ].

Compared to those taking placebo, those receiving Phaseolus vulgaris lost significantly more body weight mean loss of 2. Reported adverse effects for Phaseolus vulgaris are minor and include headaches, soft stools, flatulence, and constipation [ ]. No serious adverse effects of Phaseolus vulgaris have been reported in clinical trials, but no trials have lasted longer than 13 weeks.

Yohimbe Pausinystalia yohimbe, Pausinystalia johimbe is a West African evergreen tree. Yohimbine has hyperadrenergic physiological effects because it acts as an alpha-2 receptor antagonist [ 6 , ]. Yohimbe extract is an ingredient in some dietary supplements that are promoted for libido enhancement, body building, and weight loss [ ], but it is used primarily as a traditional remedy for sexual dysfunction in men.

The authors of a review of yohimbe concluded that no conclusive evidence indicates that yohimbe affects body weight or body mass [ ]. The author of a review of yohimbe reached similar conclusions, noting that results from small human trials of yohimbine for weight loss are contradictory and the evidence base is insufficient to support a weight loss claim for this compound [ ].

Yohimbe can be dangerous. Taking 20 to 40 mg of yohimbine has been reported to increase blood pressure slightly, whereas doses of mg or higher can cause headaches, hypertension, anxiety, agitation, tachycardia, myocardial infarction, cardiac failure, and death [ 43 , , , , ].

More recently, dietary supplements containing yohimbe accounted for 1, self-reports to U. poison control centers between and [ ]. Although yohimbe is generally well tolerated at low doses [ ], no safe dose has been established for it. Yohimbe should only be used under medical supervision because of its potential to produce serious adverse effects [ ].

Ephedra also known as ma huang , a plant native to China, is the common name for three main species: Ephedra sinica, Ephedra equisentina, and Ephedra intermedia [ ].

The active compounds, which are in the plant's stem and account for about 1. In the s, ephedra—frequently combined with caffeine—was a popular ingredient in dietary supplements sold for weight loss and to enhance athletic performance.

FDA no longer permits the use of ephedrine alkaloids in dietary supplements because of safety concerns that are detailed below, but information is provided here in response to continued interest in this ingredient.

Ephedrine acts as a stimulant in the central nervous system [ , ], and it might increase thermogenesis and act as an appetite suppressant [ ]. The authors of a meta-analysis that included 20 clinical trials concluded that ephedrine and ephedra are modestly effective for short-term weight loss 6 months or less , but no studies have assessed their long-term effects [ ].

While ephedra was available as a dietary supplement ingredient in the United States, its use with or without caffeine was associated with numerous reported adverse effects, including nausea, vomiting, psychiatric symptoms such as anxiety and mood change , hypertension, palpitations, stroke, seizures, heart attack, and death [ , ].

Although these reported adverse effects could not be linked with certainty to the use of ephedra-containing dietary supplements, FDA deemed the safety concerns serious enough to prohibit the sale of dietary supplements containing ephedrine alkaloids in [ ]. As a result of this ruling, manufacturers are no longer permitted to sell dietary supplements containing ephedrine alkaloids in the United States.

Like all dietary supplements, weight-loss supplements can have side effects and might interact with prescription and over-the-counter medications. In some cases, the active constituents of botanical or other ingredients promoted for weight loss are unknown or uncharacterized [ 29 ].

Furthermore, many weight-loss supplements contain multiple ingredients that have not been adequately tested in combination with one another. Pittler and Ernst noted that for ingredients lacking convincing evidence of effectiveness, "even minor adverse events shift the delicate risk-benefits balance against their use" [ 6 ].

People need to talk with their health care providers about the use of weight-loss dietary supplements to understand what is known—and not known—about these products. FDA and the FTC warn consumers to beware of fraudulent claims about weight-loss dietary supplements [ , ]. At best, products with claims like these do not live up to them, and, even worse, they could be dangerous.

Between January and December , dietary supplements were subject to a Class I recall by FDA, indicating a reasonable probability that use of or exposure to these products would cause serious adverse health consequences. In most cases, the recall was due to the presence of undeclared drug ingredients.

In , FDA issued 36 public notifications warning consumers not to purchase specific weight-loss products because they contained a hidden drug ingredient—often sibutramine, a weight-loss medication that was withdrawn from the U.

market in because of safety concerns [ ]. A product represented as a dietary supplement that contains one or more drug ingredients, whether or not these ingredients are declared on the label, is considered an unapproved drug and is therefore subject to enforcement action by FDA.

FDA maintains a webpage listing public notifications about tainted weight-loss products. Some ingredients in weight-loss dietary supplements can interact with certain medications.

For example, glucomannan and guar gum might decrease the absorption of many drugs that are taken orally [ , ].

Glucomannan has been reported to lower blood glucose levels [ ] and, therefore, could interact with diabetes medications [ ]. Chitosan might potentiate the anticoagulant effects of warfarin [ ]. Green tea could interact with chemotherapy drugs [ , ]. Garcinia cambogia was associated with serotonin toxicity in a patient taking the supplement together with two selective serotonin reuptake inhibitor medications [ ].

Other ingredients, such as caffeine and bitter orange, could have an additive effect if taken with other stimulants. Bitter orange has also been shown to inhibit CYP3A4 activity, leading to increased blood levels of certain drugs, such as cyclosporine and saquinavir [ 43 ].

These are just a few examples of interactions between ingredients of weight-loss dietary supplements and medications. Individuals taking dietary supplements and medications on a regular basis should discuss their use with their health care provider.

As this fact sheet shows, the evidence supporting the use of dietary supplements to reduce body weight and stimulate weight loss is inconclusive and unconvincing, and the cost of these products can be considerable [ 6 , 14 , 29 , 41 ].

The best way to lose weight and keep it off is to follow a sensible approach that incorporates a healthy eating plan, reduced caloric intake, and moderate physical activity under the guidance of a heath care provider. For some individuals with a high BMI who have additional health risks, physicians may prescribe adjunctive treatments, including FDA-approved prescription medications or bariatric surgery, in addition to lifestyle modifications [ 7 ].

Lifestyle changes that promote weight loss might also improve mood and energy levels and lower the risk of heart disease, diabetes, and some cancers [ 5 ].

The Weight Management webpage from the National Institute of Diabetes and Digestive and Kidney Diseases at the National Institutes of Health provides several helpful publications on weight control, obesity, physical activity, and related nutritional issues.

The federal government's — Dietary Guidelines for Americans notes that "Because foods provide an array of nutrients and other components that have benefits for health, nutritional needs should be met primarily through foods.

In some cases, fortified foods and dietary supplements are useful when it is not possible otherwise to meet needs for one or more nutrients e. For more information about building a healthy dietary pattern, refer to the Dietary Guidelines for Americans and the U.

Department of Agriculture's MyPlate. This fact sheet by the National Institutes of Health NIH Office of Dietary Supplements ODS provides information that should not take the place of medical advice. We encourage you to talk to your health care providers doctor, registered dietitian, pharmacist, etc.

about your interest in, questions about, or use of dietary supplements and what may be best for your overall health. Any mention in this publication of a specific product or service, or recommendation from an organization or professional society, does not represent an endorsement by ODS of that product, service, or expert advice.

Updated: May 18, History of changes to this fact sheet. Dietary Supplements for Weight Loss Fact Sheet for Health Professionals. Consumer Datos en español Health Professional Other Resources.

Table of Contents Introduction Regulation of Weight-Loss Dietary Supplements Common Ingredients in Weight-Loss Dietary Supplements Ephedra Ma Huang , an Ingredient Banned from Dietary Supplements Safety Considerations Choosing a Sensible Approach to Weight Loss References Disclaimer.

Few clinical trials, all with small sample sizes Research findings : Possible modest reduction in body weight and waist circumference. Increase satiety and gastrointestinal transit time and slow glucose absorption.

Several clinical trials with weight loss as a secondary outcome Research findings : No effect on body weight. Increases energy expenditure and lipolysis; acts as a mild appetite suppressant. Synephrine is the proposed active constituent.

Small clinical trials of poor methodological quality Research findings : Possible increase in resting metabolic rate and energy expenditure; inconclusive effects on weight loss. Some safety concerns reported, especially for combinations with other stimulants Reported adverse effects : Chest pain, anxiety, headache, musculoskeletal complaints, and increased blood pressure and heart rate.

Caffeine as added caffeine or from guarana, kola nut, yerba maté, or other herbs. Short-term clinical trials of combination products Research findings : Possible modest effect on body weight or decreased weight gain over time.

Several large clinical trials Research findings : No effect on body weight, weight loss, or prevention of weight gain based on clinical trials. Increase energy expenditure and lipid oxidation, increase satiety, and reduce energy intake.

Several clinical trials, mostly focused on energy intake and appetite Research findings : Might reduce energy intake but no effect on body weight. Several clinical trials with weight loss as a secondary outcome Research findings : Possible modest reduction in body weight.

Small clinical trials, mostly of poor methodological quality Research findings : Minimal effect on body weight. Few safety concerns reported for 0. Increases lean muscle mass; promotes fat loss; and reduces food intake, hunger levels, and fat cravings. Several clinical trials of varying methodological quality Research findings : Minimal effect on body weight and body fat.

Enhances lipolysis and reduces appetite. Forskolin is the proposed active constituent. Few short-term clinical trials Research findings : No effect on body weight. Several clinical trials Research findings : Minimal effect on body weight and body fat. Few safety concerns reported for 2.

Increases energy expenditure and fatty acid oxidation; suppresses adipocyte differentiation and lipid accumulation. Studied only in combination with pomegranate-seed oil in one trial in humans Research findings : Insufficient research to draw firm conclusions.

No safety concerns reported from one clinical trial that used 2. Garcinia cambogia hydroxycitric acid. Inhibits lipogenesis, suppresses food intake. Hydroxycitric acid is the proposed active constituent. Several short-term clinical trials of varying methodological quality Research findings : Little to no effect on body weight.

Some safety concerns reported Reported adverse effects : Headache, nausea, upper respiratory tract symptoms, gastrointestinal symptoms, mania, and liver damage.

Several clinical trials of varying methodological quality, mostly focused on effects on lipid and blood glucose levels Research findings : Little to no effect on body weight. Significant safety concerns reported for tablet forms, which might cause esophageal obstructions, but few safety concerns with up to Green coffee bean extract Coffea arabica, Coffea canephora, Coffea robusta.

Few clinical trials, all of poor methodological quality Research findings : Possible modest effect on body weight. Green tea Camellia sinensis and green tea extract.

Increases energy expenditure and fat oxidation; reduces lipogenesis and fat absorption. Several clinical trials of good methodological quality on green tea catechins with and without caffeine Research findings : Possible modest effect on body weight.

No safety concerns reported for use as a beverage, contains caffeine; some safety concerns reported for green tea extract Reported adverse effects for green tea extract : Constipation, abdominal discomfort, nausea, increased blood pressure, and liver damage.

Top Weight Loss Medications Our Powerfyl Powerful weight loss supplements the best weight Nut-free sunflower seeds supplements are:. Powedful and Drug Administration FDA. A Cochrane Review analyzed the results from weught randomized controlled trials of green Ewight preparations in a total of 1, participants with overweight or obesity [ ]. If you are a Mayo Clinic patient, this could include protected health information. The New England Journal of Medicine, March 18, Despite the association between low vitamin D levels and obesity, scientific evidence does not support a cause-and-effect relationship. How it works: People with specific genetic mutations may experience insufficient activation of the MC4 receptor in the brain, which could contribute to obesity.
Best Weight Loss Supplements market in Enhance insulin sensitivity and promote longevity of safety weigbt [ Powrrful. Bitter orange is the common name for the botanical Citrus aurantium. Caffeine increases energy expenditure and fat oxidation [ 44 ]. It is also administered as an injection. Scandinavian Journal of Medicine and Science in Sports[online] 15 2pp.
Home » The Ppwerful Vitamins Poqerful Weight Loss: What Supplememts are Good for Supplemehts Belly Fat? by The Fat loss workouts Clinic Powerful weight loss supplements 3, Struggling with stubborn belly fat can be a frustrating experience. Despite regular exercise and a balanced diet, sometimes it just refuses to budge. Many of us are constantly on the lookout for effective ways to shed those extra pounds around our midsection. In this quest, one often overlooked factor is the role of vitamins.

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