Category: Diet

Resveratrol as a natural remedy

Resveratrol as a natural remedy

Resveratrol has been Blood circulation in feet to inhibit CYP3A4 activity in vitroand in healthy Resveratrool Digestive enzyme mechanism He and rejedy colleagues discovered in that resveratrol could increase cell survival and slow aging in yeast and later in mice by activating a "longevity" gene known as SIRT1. Ma, Z. Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Resveratrol as a natural remedy

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Resveratrol as a natural remedy -

Recently published studies evaluating resveratrol's potential for primary prevention of chronic disease in healthy populations have generated both controversy in the scientific community and large-scale media attention. These findings confirm the results of previous studies in rats 8 and healthy humans.

At first glance these studies do not appear consistent with the animal model research findings. Rather studies should be undertaken to examine disease prevention and maintain health over the long-term. Most recently, a well-designed clinical trial by Gliemann et al 13 published in the Journal of Physiology generated intense media coverage.

The study reported that resveratrol may blunt the beneficial effects of exercise. If true this will add a significant piece of information to our use of resveratrol. A detailed review and analysis of this new study will be published in an upcoming issue of this journal.

In summary, both the health field and general population must be critical readers of any clinical trial to ensure accurate conclusions are drawn. Resveratrol has been shown to have a wide variety of health benefits for humans.

One question is whether these short-term positive health findings will translate into long-term health benefits. Both the scientific and general community anxiously await the results of these trials which will further our understanding of the dose-response of resveratrol and its clinical applicability in people.

Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. Liu BL, Zhang X, Zhang W, Shen HN. New enlightenment of French Paradox: resveratrol's potential for cancer chemoprevention and anti-cancer therapy. Cancer Biol Ther. Jang M, Cai L, Udeani GO, et al.

Cancer chemoprotective activity of resveratrol, a natural product derived from grapes. Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Labbe A, Garand C, Cogger VC, et al. Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome.

J Gerontol A Biol Sci Med Sci. Hector KL, Laquisz M, Nakagawa S. The effect of resveratrol on longevity across species: A meta-analysis.

Biol Lett. Halliwell B. Dietary polyphenols: good, bad, or indifferent for your health? Cardiovasc Res. Bujanda L, Hijona E, Larzabal M, et al. Resveratrol inhibits nonalcoholic fatty liver disease in rats.

BMC Gastroenterol. An anti-inflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol.

J Clin Endocrinol Metab. Ghanim H, Sia CL, Korzeniewski K, et al. Some people also take resveratrol supplements, especially for lowering blood pressure. Many of these supplements contain much higher doses of resveratrol than a person would naturally consume from food sources.

Clinical trials show that it is technically safe to take resveratrol in doses of up to 5 g per day , though taking more than 2.

A review found that milligrams or more of resveratrol effectively lowered systolic blood pressure but had no significant effects on diastolic blood pressure. More studies are necessary to determine a safe, effective dose for humans, as human trials have found many conflicting results.

Overall, people have different tolerance levels for resveratrol, and there is no universally recommended dose. A person should talk with a healthcare professional about the dose that might be safest and most beneficial for their body.

Resveratrol is a naturally occurring compound present in grapes, some berries, and other fruits and nuts. It often mimics antioxidant activity in the body and may provide many health benefits. Research most supports its use for cardiovascular protection and blood pressure regulation.

People may consume resveratrol through foods or supplements. There is no conclusive recommended dosage for resveratrol, but consuming large amounts may lead to gastrointestinal upset. A doctor, dietitian, or other qualified health professional may be helpful in determining the appropriate amount of resveratrol for an individual.

People have cultivated grapes for 8, years. Grapes come in a range of colors and types, have been turned into jams and jellies, and made into wine…. Antioxidants are in many healthful foods. Experts believe that they help the body fight harmful free radicals that can lead to various health….

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Medical News Today. Health Conditions Health Products Discover Tools Connect. What to know about resveratrol. Medically reviewed by Katherine Marengo LDN, R. What it is Benefits Side effects How to consume Dosage Summary Resveratrol is a plant compound derived from red grapes that has antioxidant-like properties.

What is resveratrol? Side effects and risks. How to consume. How we reviewed this article: Sources. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references.

We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Share this article.

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Remecy is a plant Resvratrol derived from red grapes that has antioxidant-like properties. There are numerous possible Resveratrol as a natural remedy naturall of resveratrol. Many people use resveratrol as a health-boosting supplement. Research has linked the compound to potential health benefits such as improved brain health and blood pressure. However, resveratrol may also come with some side effects. New research shows little risk of Rseveratrol from prostate biopsies. Discrimination at work Resveratroo linked to high blood nutrition for triathletes. Icy fingers nattural toes: Poor renedy or Remexy phenomenon? Resveratrol, an Resveeatrol found in red wine Resveratrol as a natural remedy certain foods, has been touted as a natural way to slow aging and fight cancer, obesity, heart disease, and diabetes. As promising as it sounds, we don't really know how resveratrol affects humans, since most studies have been conducted on animals and microbes. So a study out this week that looks at resveratrol's effect on people from two villages in the Chianti region of Italy—where they know a thing or two about red wine—got my attention.

Resveratrol as a natural remedy -

Discrimination at work is linked to high blood pressure. Icy fingers and toes: Poor circulation or Raynaud's phenomenon? Resveratrol, an antioxidant found in red wine and certain foods, has been touted as a natural way to slow aging and fight cancer, obesity, heart disease, and diabetes.

As promising as it sounds, we don't really know how resveratrol affects humans, since most studies have been conducted on animals and microbes. So a study out this week that looks at resveratrol's effect on people from two villages in the Chianti region of Italy—where they know a thing or two about red wine—got my attention.

Scientists at the Johns Hopkins University School of Medicine analyzed information from about men and women ages 65 and older whose diets were naturally rich in resveratrol from food. They measured the amounts of metabolized resveratrol that showed up in the participants' urine, expecting to see high levels of resveratrol among the healthiest people.

But that didn't happen. In fact, there was no link between resveratrol levels and the rates of heart disease, cancer, and death. The results were published online in JAMA Internal Medicine.

Richard Semba, the lead author of the study. In retrospect, this was really oversimplified. But there are still ongoing trials, so one must keep an open mind about possible benefits. You may already consume a fair amount of resveratrol. It's found in foods such as peanuts, pistachios, grapes, red and white wine, blueberries, cranberries, and even cocoa and dark chocolate.

The plants from which these foods come make resveratrol to fight fungal infection, ultraviolet radiation, stress, and injury. An army of researchers is scrambling to see if that protective power can be extended beyond plants. An early resveratrol researcher was Dr. David Sinclair, now a professor of genetics at Harvard Medical School.

He and his colleagues discovered in that resveratrol could increase cell survival and slow aging in yeast and later in mice by activating a "longevity" gene known as SIRT1.

But the dose of resveratrol administered in experiments is always much higher than you'd normally consume in a daily diet. Sinclair, who was named one of this year's Time magazine Most Influential People for his anti-aging research. He wasn't surprised about the results in the JAMA Archives study.

Still, the disappointing results don't mean that resveratrol and other molecules like it won't help extend the lifespan or protect against the development of aging-related diseases. Sinclair points out that drug companies have now created thousands of new synthetic molecules, "that are up to a thousand times better than resveratrol.

Walle T. Bioavailability of resveratrol. Ann N Y Acad Sci. Burkon A, Somoza V. Mol Nutr Food Res. Goldberg DM, Yan J, Soleas GJ. Absorption of three wine-related polyphenols in three different matrices by healthy subjects.

Walle T, Hsieh F, Delegge MH, Oatis JE, Jr. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. Boocock DJ, Faust GE, Patel KR, et al. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent.

Cancer Epidemiol Biomarkers Prev. Brown VA, Patel KR, Viskaduraki M, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.

Cancer Res. Patel KR, Andreadi C, Britton RG, et al. Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence. Sci Transl Med. Tome-Carneiro J, Larrosa M, Gonzalez-Sarrias A, Tomas-Barberan FA, Garcia-Conesa MT, Espin JC. Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence.

Curr Pharm Des. Vitaglione P, Sforza S, Galaverna G, et al. Bioavailability of trans-resveratrol from red wine in humans. Vaz-da-Silva M, Loureiro AI, Falcao A, et al. Effect of food on the pharmacokinetic profile of trans-resveratrol.

Int J Clin Pharmacol Ther. la Porte C, Voduc N, Zhang G, et al. Steady-State pharmacokinetics and tolerability of trans-resveratrol mg twice daily with food, quercetin and alcohol ethanol in healthy human subjects.

Clin Pharmacokinet. Leonard SS, Xia C, Jiang BH, et al. Resveratrol scavenges reactive oxygen species and effects radical-induced cellular responses. Biochem Biophys Res Commun. Vlachogianni IC, Fragopoulou E, Kostakis IK, Antonopoulou S.

In vitro assessment of antioxidant activity of tyrosol, resveratrol and their acetylated derivatives. Food Chem. Brito P, Almeida LM, Dinis TC. The interaction of resveratrol with ferrylmyoglobin and peroxynitrite; protection against LDL oxidation. Free Radic Res. Frankel EN, Waterhouse AL, Kinsella JE.

Inhibition of human LDL oxidation by resveratrol. Wang H, Yang YJ, Qian HY, Zhang Q, Xu H, Li JJ. Resveratrol in cardiovascular disease: what is known from current research? Heart Fail Rev. Bradamante S, Barenghi L, Villa A. Cardiovascular protective effects of resveratrol.

Cardiovasc Drug Rev. Tangkeangsirisin W, Serrero G. Resveratrol in the chemoprevention and chemotherapy of breast cancer. In: Bagchi D, Preuss HG, eds. Phytopharmaceuticals in Cancer Chemoprevention. Boca Raton: CRC Press; Yurdagul A, Jr.

Resveratrol promotes endothelial cell wound healing under laminar shear stress through an estrogen receptor-alpha-dependent pathway. Am J Physiol Heart Circ Physiol. Chen ZH, Hurh YJ, Na HK, et al. Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells.

Ciolino HP, Yeh GC. Inhibition of aryl hydrocarbon-induced cytochrome P 1A1 enzyme activity and CYP1A1 expression by resveratrol. Mol Pharmacol. Hsieh TC, Lu X, Wang Z, Wu JM. Induction of quinone reductase NQO1 by resveratrol in human K cells involves the antioxidant response element ARE and is accompanied by nuclear translocation of transcription factor Nrf2.

Med Chem. Chow HH, Garland LL, Hsu CH, et al. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res Phila. Stewart ZA, Westfall MD, Pietenpol JA. Cell-cycle dysregulation and anticancer therapy.

Trends Pharmacol Sci. Woo JH, Lim JH, Kim YH, et al. Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction.

Yu H, Pan C, Zhao S, Wang Z, Zhang H, Wu W. Resveratrol inhibits tumor necrosis factor-alpha-mediated matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. Biomed Pharmacother. Igura K, Ohta T, Kuroda Y, Kaji K.

Resveratrol and quercetin inhibit angiogenesis in vitro. Cancer Lett. Lin MT, Yen ML, Lin CY, Kuo ML. Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation.

Chen Y, Tseng SH. Pro- and anti-angiogenesis effects of resveratrol. In Vivo. Kanavi MR, Darjatmoko S, Wang S, et al. The sustained delivery of resveratrol or a defined grape powder inhibits new blood vessel formation in a mouse model of choroidal neovascularization.

Steele VE, Hawk ET, Viner JL, Lubet RA. Mechanisms and applications of non-steroidal anti-inflammatory drugs in the chemoprevention of cancer.

Mutat Res. Donnelly LE, Newton R, Kennedy GE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol. Pinto MC, Garcia-Barrado JA, Macias P. Resveratrol is a potent inhibitor of the dioxygenase activity of lipoxygenase.

Shankar S, Singh G, Srivastava RK. Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Front Biosci. de la Lastra CA, Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications.

Hartman J, Frishman WH. Inflammation and atherosclerosis: a review of the role of interleukin-6 in the development of atherosclerosis and the potential for targeted drug therapy. Cardiol Rev. Stocker R, Keaney JF, Jr. Role of oxidative modifications in atherosclerosis.

Physiol Rev. Carluccio MA, Siculella L, Ancora MA, et al. Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscler Thromb Vasc Biol. Ferrero ME, Bertelli AE, Fulgenzi A, et al.

Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium. Am J Clin Nutr. Ekshyyan VP, Hebert VY, Khandelwal A, Dugas TR. Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production. J Cardiovasc Pharmacol.

Haider UG, Sorescu D, Griendling KK, Vollmar AM, Dirsch VM. Resveratrol increases serinephosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells. Mnjoyan ZH, Fujise K. Khandelwal AR, Hebert VY, Dugas TR.

Essential role of ER-alpha-dependent NO production in resveratrol-mediated inhibition of restenosis. Duffy SJ, Vita JA. Effects of phenolics on vascular endothelial function. Curr Opin Lipidol. Klinge CM, Blankenship KA, Risinger KE, et al.

Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. J Biol Chem.

Klinge CM, Wickramasinghe NS, Ivanova MM, Dougherty SM. Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-Src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells.

FASEB J. Takahashi S, Nakashima Y. Repeated and long-term treatment with physiological concentrations of resveratrol promotes NO production in vascular endothelial cells.

Br J Nutr. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease.

Clin Chim Acta. Shen MY, Hsiao G, Liu CL, et al. Br J Haematol. Yang YM, Chen JZ, Wang XX, Wang SJ, Hu H, Wang HQ. Resveratrol attenuates thromboxane A2 receptor agonist-induced platelet activation by reducing phospholipase C activity.

Eur J Pharmacol. Kodali M, Parihar VK, Hattiangady B, Mishra V, Shuai B, Shetty AK. Resveratrol prevents age-related memory and mood dysfunction with increased hippocampal neurogenesis and microvasculature, and reduced glial activation.

Sci Rep. Ma T, Tan MS, Yu JT, Tan L. Resveratrol as a therapeutic agent for Alzheimer's disease. Biomed Res Int. Chen J, Zhou Y, Mueller-Steiner S, et al. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.

Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. Vingtdeux V, Giliberto L, Zhao H, et al.

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism. Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.

Neurochem Int. Capiralla H, Vingtdeux V, Zhao H, et al. J Neurochem. Ruszkiewicz J, Albrecht J. Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders. Albani D, Polito L, Batelli S, et al. The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta peptide.

Zhuang H, Kim YS, Koehler RC, Dore S. Potential mechanism by which resveratrol, a red wine constituent, protects neurons. Sakata Y, Zhuang H, Kwansa H, Koehler RC, Dore S. Resveratrol protects against experimental stroke: putative neuroprotective role of heme oxygenase 1. Exp Neurol. Kumar A, Naidu PS, Seghal N, Padi SS.

Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Bishayee A. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials.

Bishayee A, Darvesh AS, Politis T, McGory R. Resveratrol and liver disease: from bench to bedside and community. Liver Int. Hecht SS, Kenney PM, Wang M, et al. Berge G, Ovrebo S, Eilertsen E, Haugen A, Mollerup S. Br J Cancer. Schneider Y, Duranton B, Gosse F, Schleiffer R, Seiler N, Raul F.

Resveratrol inhibits intestinal tumorigenesis and modulates host-defense-related gene expression in an animal model of human familial adenomatous polyposis.

Nutr Cancer. Sengottuvelan M, Nalini N. Dietary supplementation of resveratrol suppresses colonic tumour incidence in 1,2-dimethylhydrazine-treated rats by modulating biotransforming enzymes and aberrant crypt foci development. Ziegler CC, Rainwater L, Whelan J, McEntee MF.

J Nutr. Patel KR, Brown VA, Jones DJ, et al. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

Howells LM, Berry DP, Elliott PJ, et al. Phase I randomized, double-blind pilot study of micronized resveratrol SRT in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics. Popat R, Plesner T, Davies F, et al.

A phase 2 study of SRT resveratrol with bortezomib for patients with relapsed and or refractory multiple myeloma. Smoliga JM, Blanchard O. Enhancing the delivery of resveratrol in humans: if low bioavailability is the problem, what is the solution?

Ronksley PE, Brien SE, Turner BJ, Mukamal KJ, Ghali WA. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis.

Lippi G, Franchini M, Favaloro EJ, Targher G. Moderate red wine consumption and cardiovascular disease risk: beyond the "French paradox". Semin Thromb Hemost. Salvamani S, Gunasekaran B, Shaharuddin NA, Ahmad SA, Shukor MY. Antiartherosclerotic effects of plant flavonoids.

Gronbaek M, Becker U, Johansen D, et al. Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer. Ann Intern Med. Lin CT, Sun XY, Lin AX. Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study.

Ren Fail. Kjaer TN, Ornstrup MJ, Poulsen MM, et al. Resveratrol reduces the levels of circulating androgen precursors but has no effect on, testosterone, dihydrotestosterone, PSA levels or prostate volume.

A 4-month randomised trial in middle-aged men. No Beneficial Effects of Resveratrol on the Metabolic Syndrome: A Randomized Placebo-Controlled Clinical Trial. J Clin Endocrinol Metab. Evans HM, Howe PR, Wong RH.

Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A Week Randomised Placebo-Controlled Intervention Trial.

Elgebaly A, Radwan IA, AboElnas MM, et al. Resveratrol Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: Systematic Review and Meta-analysis.

J Gastrointestin Liver Dis. Bo S, Ponzo V, Ciccone G, et al. Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients.

A randomized, double blind, placebo-controlled trial. Pharmacol Res. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. Banaszewska B, Wrotynska-Barczynska J, Spaczynski RZ, Pawelczyk L, Duleba AJ. Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial.

Khojah HM, Ahmed S, Abdel-Rahman MS, Elhakeim EH. Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study. Clin Rheumatol. Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA.

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. Wang S, Moustaid-Moussa N, Chen L, Mo H, Shastri A, Su R, Bapat P, Kwun I, Shen CL.

Novel insights of dietary polyphenols and obesity. J Nutr Biochem. Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E.

Inhibition of influenza A virus replication by resveratrol. J Infect Dis. Mastromarino P, Capobianco D, Cannata F, Nardis C, Mattia E, De Leo A, Restignoli R, Francioso A, Mosca L. Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia.

Antiviral Res. Semba RD, Ferrucci L, Bartali B, Urpí-Sarda M, Zamora-Ros R, Sun K, Cherubini A, Bandinelli S, Andres-Lacueva C. Resveratrol levels and all-cause mortality in older community-dwelling adults. JAMA Intern Med. Sahebkar A. Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials.

Nutr Rev. Miraglia Del Giudice M, Maiello N, Capristo C, Alterio E, Capasso M, Perrone L, Ciprandi G. Resveratrol plus carboxymethyl-ß-glucan reduces nasal symptoms in children with pollen-induced allergic rhinitis.

Curr Med Res Opin. Méndez-del Villar M, González-Ortiz M, Martínez-Abundis E, Pérez-Rubio KG, Lizárraga-Valdez R. Effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and insulin secretion.

Metab Syndr Relat Disord. Magyar K, Halmosi R, Palfi A, Feher G, Czopf L, Fulop A, Battyany I, Sumegi B, Toth K, Szabados E. Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease.

Clin Hemorheol Microcirc. Liu K, Zhou R, Wang B, Mi MT. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials.

Faghihzadeh F, Adibi P, Rafiei R, Hekmatdoost A. Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease. Nutr Res. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ.

Resveratrol does not benefit patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. Hudson, G. Resveratrol Supplementation And Changes In Glucose, Insulin, And mRNA Expression Following Exercise In Overweight Females: Cochrane Central Register of Controlled Trials ; Yoon, S.

Journal of Urology ; Klink, J. Journal of Urology ; Seely, K. Cannabinoid receptor inverse agonists as novel therapeutic agents.

The Sciences and Engineering ;70 4-B Pregliasco, F. and Cogo, R. Cochrane Central Register of Controlled Trials ; Steigerwald, M. Effects Of Resveratrol On Oxidative Stress And Vascular Function Following Exercise In Simulated Air Pollution: Three Months Oral Supplementation of a Unique Polyphenol Mixture Improves Physical and Neurocognitive Performance Indicators in Sedentary Adults: Grujic Milanovic, J.

Journal of Hypertension ;28 Pendurthi, U. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine.

Biol ; Rotondo, S. Effect of trans-resveratrol, a natural polyphenolic compound, on human polymorphonuclear leukocyte function. Bhatt, J. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Hector, K. The effect of resveratrol on longevity across species: a meta-analysis.

Roehr, B. Cardiovascular researcher fabricated data in studies of red wine. BMJ ;e Crandall, J. Pilot study of resveratrol in older adults with impaired glucose tolerance.

A Biol. Fujitaka, K. Modified resveratrol Longevinex improves endothelial function in adults with metabolic syndrome receiving standard treatment. Res ; Timmers, S. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.

Cell Metab ; Xuzhu, G. Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. Dis ; Knight, C. Mediobasal hypothalamic SIRT1 is essential for resveratrol's effects on insulin action in rats.

Diabetes ; Howells, L. Phase I randomized, double-blind pilot study of micronized resveratrol SRT in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics. Cancer Prev. Res Phila ; Wuertz, K. The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo.

Spine Phila Pa Brasnyo, P. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Fabbrocini, G. Resveratrol-containing gel for the treatment of acne vulgaris: a single-blind, vehicle-controlled, pilot study.

Am J Clin. Dermatol ; Kitada, M. Shindler, K. Oral resveratrol reduces neuronal damage in a model of multiple sclerosis. J Neuroophthalmol. Brown, V. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.

Cancer Res ; Patel, K. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Knobloch, J. Resveratrol impairs the release of steroid-resistant inflammatory cytokines from human airway smooth muscle cells in chronic obstructive pulmonary disease. J Pharmacol.

Ther ; Wong, R. Metab Cardiovasc. la, Porte C. Steady-State pharmacokinetics and tolerability of trans-resveratrol mg twice daily with food, quercetin and alcohol ethanol in healthy human subjects. Le Couteur, D. and Sinclair, D. A blueprint for developing therapeutic approaches that increase healthspan and delay death.

J Gerontol. Med Sci. Kennedy, D. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. Daffner, K. Promoting successful cognitive aging: a comprehensive review. J Alzheimers. Yu, H. Resveratrol prevents endothelial dysfunction and aortic superoxide production after trauma hemorrhage through estrogen receptor-dependent hemeoxygenase-1 pathway.

Crit Care Med ; Albani, D. Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence. Guo, J. Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy.

Jha, R. Protective effect of resveratrol in severe acute pancreatitis-induced brain injury. Pancreas ; Zhang, H. Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. Bournival, J. Cell Mol.

Almeida, L. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers.

Food Res ;53 Suppl 1:S Vingtdeux, V. Therapeutic potential of resveratrol in Alzheimer's disease. Fan, E. Beneficial effects of resveratrol on atherosclerosis. J Med Food ; Vaz-da-Silva, M. Effect of food on the pharmacokinetic profile of trans-resveratrol.

J Clin. Orallo, F. Trans-resveratrol: a magical elixir of eternal youth? Med Chem. Rocha-Gonzalez, H. Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases. Calabrese, V. Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity.

Pearson, K. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Dong, W. Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors.

J Vasc. Resveratrol attenuates hepatic injury after trauma-hemorrhage via estrogen receptor-related pathway. Shock ; Bass, T.

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Ageing Dev ; Gruber, J. Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans.

Ann N Y. Acad Sci ; Baur, J. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. Valenzano, D. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.

Curr Biol ; Rakici, O. Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery.

J Cardiol ; Ma, Z. and Ma, Q. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. Molnar, V. and Garai, J.

Plant-derived anti-inflammatory compounds affect MIF tautomerase activity. Provinciali, M. J Cancer ; Aggarwal, B. Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.

Anticancer Res. Walle, T. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. Jannin, B. Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake.

Evers, D. Piver, B. Involvement of cytochrome P 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Wood, J. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature ; Olas, B. The protective effects of resveratrol against changes in blood platelet thiols induced by platinum compounds.

Physiol Pharmacol. Cavallaro, A.

Mayo Clinic offers Resveratrol as a natural remedy in Arizona, Digestive enzyme mechanism and Minnesota and at Mayo Gemedy Health System locations. Digestive enzyme mechanism might be naturap to what could natura red wine heart healthy. Resvratrol the natiral and hype about red wine and how it affects the heart. Red wine, in limited amounts, has long been thought of as healthy for the heart. The alcohol and certain substances in red wine called antioxidants may help prevent coronary artery disease, the condition that leads to heart attacks. Links between red wine and fewer heart attacks aren't well understood.

Author: Kijar

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