Category: Diet

Herbal anti-cancer supplements

Herbal anti-cancer supplements

All too often patients hide Herbal anti-cancer supplements supplements and herbs Dairy-free bread Appetite suppressants that work to supplments from their doctor. org, research suggests that certain Herbao such as breast cancer, can have a Anti-dancer risk Herbal anti-cancer supplements occurring when the body has low levels Supplements vitamin D. Herbal anti-cancer supplements China, it is being used to strengthen the immune system of cancer patients who receive chemotherapy or radiation therapy. Hypnotherapy uses guided meditation to help you relax and gain more control over your thoughts, feelings, and behaviors; it may be effective for pain and emotional stress. Xiao et al. Some research suggests that some forms of cancer are linked to those with low levels of vitamin D, while other evidence suggests vitamin D may reduce the occurrence of advanced cancer. Lin is a hematopoietic cell transplant and cellular therapy specialist at Memorial Sloan Kettering MSK Cancer Center for patients with advanced blood cancers including leukemias and lymphomas. Herbal anti-cancer supplements

Herbal anti-cancer supplements -

These observations suggest that intake of cardamom oil affects the enzymes associated with xenobiotic metabolism and may therefore have benefits as a deterrent to cancer Banerjee et al.

Cardamom has also been demonstrated to decrease azoxymethane-induced colon carcinogenesis by virtue of its anti-inflammatory, antiproliferative, and proapoptotic activities. Providing aqueous cardamom suspensions can enhance detoxifying enzyme GST activity and decrease lipid peroxidation Bhattacharjee, Rana, and Sengupta While the effects of cardamom and black pepper were the opposite on T helper-1 and -2 cytokine release by splenocytes, the presence of both spices significantly enhanced the cytotoxic activity of natural killer cells against YAC-1 lymphoma cells.

These findings provide evidence that cardamom may have anticancer benefits by modifying immunocompetence. Cinnamon is a spice obtained from the bark of an evergreen tree belonging to the Lauraceae family. Major constituents in cinnamon include cinnamaldehyde, eugenol, terpinene, α-pinene, carvacrol, linalool, safrole, benzyl benzoate, and coumarin Tabak, Armon, and Neeman Cinnamon is widely used in traditional Chinese medicine.

Several studies have examined its antioxidant properties. Providing rats with cinnamon bark powder significantly increased several antioxidant-related enzymes, including catalase, superoxide dismutase, and GST in both liver and heart tissue, compared to controls.

These enzymes help maintain GSH levels, essential for cellular integrity and protection against oxidative damage from free radicals Dhuley The ability of cinnamon extracts to suppress the in vitro growth of H.

pylori , a recognized risk factor for gastric cancer, gastric mucosa-associated lymphoid tissue lymphoma, and possibly pancreatic cancer, has stirred considerable interest in the potential use of this spice to suppress human cancers Farinha and Gascoyne ; Eslick pylori Nir et al.

In this study, the colonization rate of H. pylori was measured by urea breath tests UBTs. Although a decline in H. pylori counts was observed in six patients with exceptionally high counts according to their first UBT, the study did not demonstrate a decrease in colonization overall, and in some individuals increased colony counts occurred.

The lack of success of cinnamon as a single treatment regimen against H. pylori is not terribly surprising given the consistent failure of single-agent antibiotic trials. Additional trials using higher cinnamon amounts and possibly in combination with other agents may be warranted to truly evaluate the effects of this spice Nir et al.

Tabak et al. Cinnamon and thyme were found to be the most potent inhibitors of H. pylori growth and urease activity. pylori and the antiurease activity of two different cinnamon extracts methylene chloride and ethanol and their chemical constituents.

They found that adding μg cinnamon per disk produced an inhibition zone of approximately 80 mm wide, which was greater than the inhibition zones produced by several antibiotics 10 μg ampicillin, 30 μg tetracycline, 15 μg erythromycin, 30 μg nalidixic acid, and 25 μg co-trimoxazole.

In a liquid medium, cinnamon extract began to inhibit H. The efficiency of cinnamon extracts in inhibiting H. pylori in a liquid medium and its resistance to low pH may enhance its effects in an environment like the human stomach. The antibacterial effects of cinnamon extract may be due to cinnamaldehyde.

Cao, Urban, and Anderson studied the role of polyphenolic polymers from commercial cinnamon extract in immune regulation using mouse RAW Because TTP downregulates proinflammatory cytokines, it has the potential for use in the prevention and treatment of inflammation-related diseases.

In this study, CPE rapidly increased TTP mRNA and protein levels in mouse RAW CPE also increased the mRNAs coding for proinflammatory cytokines, such as tumor necrosis factor α, cyclooxygenase-2, and interleukin 6, although the TTP levels were 6- to fold higher than the proinflammatory cytokine mRNA molecules in the same cells Cao and Prior In mammals, glucose is a critically important molecule in the host immune response to injury and infection, which is facilitated by GLUT family proteins, and based on this study, cinnamon increases GLUT expression.

Vascular endothelial growth factor VEGF is a critical factor in the induction of angiogenesis. Unfortunately, the side effects associated with most anti-VEGF drugs limit their use, and thus, the use of naturally occurring dietary inhibitors derived from diets has great appeal.

A water-based extract from cinnamon is a promising effective agent because it directly inhibits kinase activity of purified VEGFR2 as well as mitogen-activated protein kinase- and Stat3-mediated signaling pathway in endothelial cells ECs; Lu et al.

Impressively, the extract was found to inhibit VEGF-induced EC proliferation, migration and tube formation in vitro, sprout formation from aortic ring ex vivo, and tumor-induced blood vessel formation in vivo.

Polyphenols in the extract appear to be responsible for the response; cinnamaldehyde is observed to have little effect on VEGFR2 kinase activity Lu et al. While the ability of cinnamon to influence angiogenesis is intriguing, additional studies are warranted.

Clove is derived from flower buds of the Eugenia caryophyllata tree. Several bioactive components are found in clove, including tannins, terpenoids, eugenol, and acetyleugenol Kluth et al. Cloves are native to Indonesia and are used in cuisines throughout the world.

While no studies have been conducted in humans to date to evaluate use of cloves in cancer prevention, a few studies conducted in mice suggest its effectiveness, especially in modifying cellular detoxification processes. Feeding 40 mg clove per gram of diet to mice resulted in an increase in GST activity compared to those that were not fed the spice.

In another study, feeding clove 0. A dose-dependent response was observed for several detoxification enzymes. After 20 days, all exposures resulted in a significant increase in GST and cytochrome b 5 Kumari A significant decrease in CYP activity was observed in those provided with any clove after 30 days.

No changes were observed in the activity levels of aryl hydrocarbon hydroxylase in response to the clove administration. Malondialdehyde MDA formation was measured to monitor radiation-induced lipid peroxidation, and both the concentration of clove provided and the duration of exposure affected the results.

Eugenol, an allyl chain-substituted guaiacol, may be responsible, at least in part, for the induction of the phase II enzymes Han et al. Changes in phase I and II enzymes may account for the ability of eugenol to serve as an antimutagen Miyazawa and Hisama and to inhibit carcinogen-induced genotoxicity Han et al.

Evidence also exists that clove extracts might interfere with β-catenin activity and thereby decrease colon carcinogenesis, but further studies are needed on this Aggarwal Similar to allspice, clove contains high amounts of eugenol.

However, this compound cannot serve to increase gastrointestinal GPx promoter activity, suggesting other compounds in clove may account for its biological activity Kluth et al. Overall, the findings to date suggest that tissues adapt to exposures to one or more constituents in cloves.

In doing so, clove may improve the ability of selected tissues to handle foreign compounds that might lead to the initiation of carcinogenesis. Based on findings to date, additional clinical studies are warranted to determine the ability of clove to influence drug detoxification pathways.

Coriander Coriandrum sativum is an herb in the family Apiaceae and is native to southern Europe and northern Africa to southwestern Asia. Although all parts of the plant are edible, its fresh leaves and dried seeds are most frequently used in cooking.

Coriander is a common ingredient in many foods throughout the world. One of its principal constituents is linalool. Several animal studies provide evidence that coriander seeds can promote the hepatic antioxidant system.

Coriander can also influence foreign compound metabolism. In another study, Banerjee et al. No significant changes were observed in CYP or aryl hydrocarbon hydroxylase. Although relatively few studies focus on coriander for its anticancer properties, those that are available suggest coriander may be important Esiyok, Otles, and Akcicek Cumin Cuminum cyminum is a flowering plant in the family Apiaceae and is native to the eastern Mediterranean region and India.

Thymoquinone TQ is the most abundant component of black cumin seed oil. TQ has been reported to exhibit antioxidant, antimicrobial, anti-inflammatory, and chemopreventive properties Allahghadri et al.

In another study by Banerjee et al. No statistically significant changes were observed in CYP activity, aryl hydrocarbon hydroxylase levels, or sulfhydryl levels in the liver compared to the control group, and thus, the first, and possibly most important, change may be an elevation in GST activity Banerjee et al.

Aruna et al. Considerable evidence points to the ability of TQ to suppress tumor cell proliferation, including colorectal carcinoma, breast adenocarcinoma, osteosarcoma, ovarian carcinoma, myeloblastic leukemia, and pancreatic carcinoma Gali-Muhtasib, Roessner, and Schneider-Stock Normal cells appear to be slightly resistant to TQ Worthen, Ghosheh, and Crooks Several mechanisms may explain the ability of TQ to bring about a change in cell division in neoplastic cells, including downregulation in Bcl-xL, cyclin D1, and VEGF Aggarwal et al.

Considerable evidence points to the ability of TQ to induce free radical formation in tumor cells. Thus, the biological response in tumor cells pro-oxidants may be different than that in normal cells antioxidant; Koka et al.

TQ has also been found to be effective in inhibiting human umbilical vein EC migration, invasion, and tube formation, suggesting its role in angiogenesis Yi et al. The multitude of effects caused by cumin serves as justification for its continued examination as a spice with widespread potential for health promotion.

Dill Anethum graveolens is a relatively short-lived perennial spice. Dill is an herb that in effect has two components that are dependent on the seasons.

In the early spring, dill is used for its leaves and in the autumn for its seeds. The principal constituents of dill weed oil are anethofuran or 3,6-dimethyl-2,3,3a,4,5,7a-hydroxobenzofuran, and carvone or p -mentha-1,8-dienone Zheng, Kenney, and Lam As with other spices, there is evidence that dill promotes drug detoxification mechanisms.

The response depended on the agent and the tissue examined. Because GSH helps maintain cellular oxidation-reduction balance and protects cells against free-radical species, the combination of increased GST and GSH levels results may be particularly helpful in detoxifying foreign compounds, including carcinogens.

Garlic Allium sativum is a member of the onion family Alliaceae. Garlic has been used throughout history for both its culinary and medicinal properties. The primary sulfur-containing constituents are γ-glutamyl-S-alk en yl-L-cysteines and S-alk en yl-L-cysteine sulfoxides. Considerable variation in the S-alk en ylcysteine sulfoxide content can occur; alliin S-allylcysteine sulfoxide is the largest contributor.

Alliin concentrations can increase during storage because of the transformation of γ-glutamylcysteines. Although garlic does not typically serve as a major source of essential nutrients, it may contribute to several dietary factors with potential health benefits, including the presence of oligosaccharides, arginine-rich proteins and, depending on soil and growing conditions, selenium and flavonoids.

Preclinical models provide rather compelling evidence that garlic and its associated components can lower the incidence of breast, colon, skin, uterine, esophagus, and lung cancers. However, evidence in human investigations is less compelling. Suppression of nitrosamine formation continues to surface as one of the most likely mechanisms by which garlic retards cancer.

The ability of S-allyl cysteine SAC and its nonallyl analog S-propyl cysteine to retard N-nitroso compounds formation, but not diallyl disulfide DADS , dipropyl disulfide, and diallyl sulfide DAS , reveal the critical role that the cysteine residue plays in inhibition Milner Some of the most compelling evidence in humans comes from studies by Mei et al.

More recent evidence suggests as little as 1 g of garlic may be sufficient to suppress nitroproline formation Cope et al. The ability of garlic to inhibit tumors due to different cancer-inducing agents and in different tissues indicates that a generalized cellular event is likely responsible for the change in tumor incidence and that the response is highly dependent on environmental or other types of biological insults.

Because metabolic activation is required for many of these carcinogens, there is likelihood that either phase I or II enzymes are altered.

Interestingly, little change in CYP1A1, 1A2, 2B1, or 3A4 activities has been detected following treatment with garlic or related sulfur compounds. However, this lack of responsiveness may relate to the amount and duration of exposure, the quantity of carcinogen administered, or the methods used to assess the cytochrome content or activity.

Wu et al. Their data demonstrated that the number of sulfur atoms in the allyl compound is inversely related to the depression in these cytochromes. Several lipid- and water-soluble organosulfur compounds have been examined for their antiproliferative efficacy.

Some of the more commonly used lipid-soluble allyl sulfur compounds in tumorigenesis research are ajoene, DAS, DADS, and diallyl trisulfide DATS. A breakdown of allicin appears to be necessary for achieving maximum tumor inhibition.

Earlier studies reported that lipid-soluble DAS, DADS, and DATS μM were more effective in suppressing canine tumor cell proliferation than isomolar water-soluble SAC, S-ethyl cysteine and S-propyl cysteine Knowles and Milner Undeniably, not all allyl sulfur compounds from garlic are equally effective in retarding tumor proliferation.

Allyl sulfur compounds preferentially suppress neoplastic over non-neoplastic cells Sakamoto, Lawson, and Milner p34 cdc2 kinase is a complex that governs the progression of cells from the G 2 phase into the M phase of the cell cycle Knowles and Milner Using LNCaP and HCT human cancer cells, Xiao, Zeng, and Singh demonstrated that checkpoint kinase 1-mediated mitotic arrest resulting from DATS is the key to apoptosis induction.

It is becoming increasingly clear that the response to allyl sulfurs relates to their ability to form free radicals rather than to serve as an antioxidant Antosiewicz et al. Allyl sulfurs may bring about changes by influencing the genomic expression by affecting histone homeostasis.

Allyl mercaptan is a particularly potent inhibitor of histone deacetylase HDAC; Nian et al. HDAC inhibition has the potential to derepress epigenetically silenced genes in cancer cells, leading to cell-cycle arrest and apoptosis. Sp3 appears to have a role in driving p21 gene expression after HDAC inhibition by allyl sulfur compounds and coincides with cell-cycle arrest.

Alliin has been reported to influence angiogenesis. It causes a dose-dependent inhibition of fibroblast growth factor 2 FGF-2 -induced human EC tube formation and angiogen- esis in the chick chorioallantoic membrane model Mousa and Mousa Xiao et al.

However, while DATS was effective in decreasing prostate cancer multiplicity in the transgenic adenocarcinoma of the mouse prostate model, it did not appear to relate to a change in angiogenesis Singh et al.

Ginger Zingiber officinale is a member of the Zingiberaceae family and is consumed widely not only as a spice but also as a medicinal agent see also Chapter 7 on ginger. Other members of the family include turmeric and cardamom. The principal constituents of ginger include [6]-gingerol, [6]-paradol, [6]-shogaol dehydration gingerols , and zingerone.

Gingerol has also been shown to decrease intracellular ROS formation in human keratinocyte cells Kim et al. Ippoushi et al.

Various animal models have been used to examine the role of ginger in cancer prevention. For example, Ihlaseh et al. Banerjee et al. Inflammation is a significant risk factor for cancer, including prostate cancer.

Mitogen-activated protein kinase phosphatase-5 MKP5 is implicated as a proinflammatory inhibitor in innate and adaptive immune response in vivo Zhang et al.

Providing [6]-gingerol upregulated MKP5 expression in normal prostate epithelial cells treated with 50 μM gingerol; likewise, it upregulated MKP5 expression in human prostate cancer cell lines DU, PC-3, LNCaP and LAPC-4; Nonn, Duong, and Peehl Ginger extracts, more so than their individual components, have been shown to inhibit lipopolysaccharide-induced prostaglandin E 2 PGE 2 production to an extent similar to that of indomethacin, a nonsteroidal anti-inflammatory drug.

Subfractions of ginger extract decreased LPS-induced COX-2 mRNA expression levels, although apparently not through the nuclear factor κB NF-κβ or activating protein 1 AP-1 transcription factor pathways, because the ginger extracts did not inhibit TNF-α production Lantz et al.

It is unclear whether [6]-paradol has molecular targets similar to [6]-gingerol. Ginger also appears to have antitumorigenic properties. Several cell lines have been examined for their sensitivity to ginger.

In a study of cytotoxic activities of several compounds in ginger against four tumor cell lines A, human lung cancer; SK-OV-3, human ovarian cancer; SK-MEL-2, human skin cancer; and HCT, human colon cancer , [6]-shogaol was the most potent ED 50 : 1. Adding [6]-gingerol 25 μM has been reported to inhibit proliferation in rat ascites hepatoma cells AHA and increase apoptosis at higher concentrations 50 μM; Yagihashi, Miura, and Yagasaki Likewise, adding [6]-shogoal 60 μM to COLO cells has been reported to increase the expression of GADD, a gene that promotes apoptosis Chen et al.

Ginger is also recognized for its potential usefulness to reduce nausea. To determine whether ginger had antiemetic effects in cisplatin-induced emesis, Manusirivithaya et al. In the delayed phase, ginger and metoclopramide have no statistically significant difference in efficacy Manusirivithaya et al.

In another study, mg of ginger was compared to mg intravenous IV metoclopramide, and to 4-mg IV ondansetron in controlling nausea in patients receiving cyclophosphamide chemotherapy. Ginger was determined to be as effective as metoclopramide, but neither was as effective as ondansetron Sontakke, Thawani, and Naik Overall, while the anticancer findings of ginger are intriguing and several processes may be associated with the observed responses, additional studies are needed to clarify the underlying mechanisms and to determine overall benefits to humans Pan et al.

Rosemary Rosmarinus officinalis is a woody herb with fragrant needle-like leaves. Rosemary is native to the Mediterranean region and possesses a bitter, astringent taste and highly aromatic characteristics that complement a wide variety of foods.

Rosemary is a member of the family Lamiaceae, and it contains a number of potentially biologically active compounds, including antioxidants such as carnosic acid and rosmarinic acid.

Due to its high antioxidant activity, crude and refined extracts of rosemary are now widely available commercially Ho et al. While the data are difficult to interpret, when rosemary is added along with other herbs to a balsamic vinegar preparation used in soups and salads, it appears to provide protection again oxidative stress in humans Dragan et al.

Considerable evidence also suggests that rosemary extracts, or its isolated components, can retard chemically induced cancers. For example, topical application of a rosemary extract has been reported to block the initiation and promotion phases of B a P- and DMBA-mediated skin tumorigenesis Huang et al.

Likewise, topical application of pure carnosol and ursolic acid also inhibited tetradecanoylphorbol acetate TPA -induced skin tumor promotion in DMBA-initiated mice Huang et al.

Adding rosemary or carnosol has also been shown to retard DMBA-induced mammary cancer in rats Singletary, MacDonald, and Wallig The depression in tumors may occur because of a change in the types and amounts of DMBA adducts bound to DNA Amagase et al. Although not extensively studied, such evidence suggests the ability of rosemary to influence drug-metabolizing enzymes.

Rosemary extracts and the active compounds carnosic acid and rosmarinic acid have been found to inhibit the proliferation of various human cancer cell lines, including NCI-H82 human, small cell lung carcinoma , DU human prostate carcinoma , Hep-3B human [black] liver carcinoma , K human chronic myeloid leukemia , MCF-7 human breast adenocarcinoma , PC-3 human prostate adenocarcinoma , and MDA-MB human breast adenocarcinoma; Yesil-Celiktas et al.

Part of the antitumorigenic properties associated with rosemary may relate to a decrease in TNF-α-induced ROS generation and NF-κB activation, and thus enhanced TNF-α-induced apoptosis Moon et al.

Carnosol was the most effective in reducing tumor proliferation. Carnosol is also known to induce apoptotic cell death in high-risk pre-B acute lymphoblastic leukemia ALL; Dorrie, Sapala, and Zunino At least part of this response may relate to a decrease in Bcl Although carnosol may be effective, it may also interfere with the actions of some other antitumor agents.

Zunino and Storms reported that carnosol decreased the percentage of cell death in the pre-B ALL lines SEM, RS4 ;11, and REH when combined with cytarabine, methotrexate, or vincristine compared to these chemotherapeutic agents alone.

Overall, these data suggest that carnosol, and possibly other constituents in rosemary, may block the terminal apoptotic events induced by some chemotherapeutic drugs and therefore may decrease the effectiveness of some standard therapies for leukemia.

Saffron is a spice derived from the flower of the saffron crocus Crocus sativus plant native to Southwest Asia. Saffron imparts a bitter taste and hay-like fragrance to food. Saffron likely contains more than volatile and aroma-yielding compounds.

Significant information points to the ability of saffron to inhibit cancer Abdullaev Aqueous saffron preparations have been reported to inhibit chemically induced skin carcinogenesis Das, Chakrabarty, and Das Both changes in carcinogen bioactivation and tumor proliferation appear to occur.

Saffron infusion given orally either before or after DMBA treatment increased GST, GPx, catalase, and superoxide dismutase in liver Das, Das, and Saha Saffron and crocus also have significant antitumorigenic properties.

Similar to other spices, they appear to suppress cell growth in neoplastic cells to a greater extent than in normal cells Aung et al. The ability of crocin to decrease cell viability occurs in a concentration- and time-dependent manner Bakshi et al.

The effects of tumor suppression also have an impact on the longevity of the host. The mechanism by which saffron suppresses tumor proliferation has not been adequately explored, but a shift in caspases and an increase in Bax protein are possible Mousavi et al.

Analysis of DNA fragmentation by flow cytometry revealed apoptotic cell death in these cells Mousavi et al. Saffron-induced apoptosis was inhibited by pan-caspase inhibitors, indicating the importance of this process in determining the response. Thyme is another culinary and medicinal herb. Today, common usage refers to any or all members of the plant genus Thymus , also of the Lamiaceae family.

Several active agents are reported, including thymol, carvacrol, apigenin, luteolin, tannins, γ-terpinene, and other oils Aydin, Basaran, and Basaran ; Kluth et al. Feeding thyme leaves 0.

Admittedly, the isolated components were more effective than feeding the leaf. They observed a thyme extract to activate CYP3A4 promoter via PXR and the GI-GPx promoter via the electrophile responsive element, thus providing potential clues about the mechanism by which thymol and carvacrol may influence phase I and II enzyme expression Kluth et al.

The number of studies on genotoxic effects of thymol and carvacrol are limited, but contradictory. typhimurium tests have provided some, but not compelling, evidence that thyme is weakly mutagenic Stammati et al. In vivo, 0. In comet assays with human lymphocytes, thymol and carvacrol did not induce DNA strand breakage at concentrations lower than μM, and were therefore considered safe for consumers Undeger et al.

Mounting evidence suggests that cancers are not an inevitable consequence of aging but are preventable diseases. Spices have been consumed for centuries for a variety of purposes, such as flavoring agents, colorants, and preservatives. This chapter only scratches the surface of the overall impact of herbs and spices since there are approximately spices commonly being used for culinary purposes.

Without question, evidence exists that multiple processes, including proliferation, apoptosis, angiogenesis, and immunocompetence, can be influenced by one or more spices. While the currently available data are intriguing, considerably more information is needed to determine who will benefit most from exaggerated intake of one or more spices, the effective exposures needed to bring about the desired outcome s , and what interactions both positive and negative exist with other components of the diet or with medications that an individual may regularly consume.

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Show details Benzie IFF, Wachtel-Galor S, editors. Search term. Chapter 17 Herbs and Spices in Cancer Prevention and Treatment Christine M.

FIGURE BASIL Basil Ocimum basilicum is a culinary herb prominently featured in Italian and Southeast Asian cuisines. CARDAMOM Cardamom refers to herbs within the Elettaria green and Amomum black genera of the ginger family Zingiberaceae.

CINNAMON Cinnamon is a spice obtained from the bark of an evergreen tree belonging to the Lauraceae family. CLOVE Clove is derived from flower buds of the Eugenia caryophyllata tree.

CORIANDER Coriander Coriandrum sativum is an herb in the family Apiaceae and is native to southern Europe and northern Africa to southwestern Asia. CUMIN Cumin Cuminum cyminum is a flowering plant in the family Apiaceae and is native to the eastern Mediterranean region and India.

DILL Dill Anethum graveolens is a relatively short-lived perennial spice. GARLIC Garlic Allium sativum is a member of the onion family Alliaceae.

GINGER Ginger Zingiber officinale is a member of the Zingiberaceae family and is consumed widely not only as a spice but also as a medicinal agent see also Chapter 7 on ginger. ROSEMARY Rosemary Rosmarinus officinalis is a woody herb with fragrant needle-like leaves. SAFFRON Saffron is a spice derived from the flower of the saffron crocus Crocus sativus plant native to Southwest Asia.

THYME Thyme is another culinary and medicinal herb. Crocus sativus against cancer. Arch Med Res. Aggarwal B. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other neutraceuticals. Annu Rev Nutr. Epub, Apr B, Kunnumakkara A. B, Harikumar K. B, Tharakan S. T, Sung B, Anand P.

Potential of spice-derived phytochemicals for cancer prevention. Planta Med. Ahmed R. S, Suke S. G, Seth V, Chakraborti A, Tripathi A. K, Banerjee B. Protective effects of dietary ginger Zingiber officinales Rosc. on lindane-induced oxidative stress in rats.

Phytother Res. Al-Rehaily A. J, Al-Said M. S, Al-Yahya M. A, Mossa J. A, Rafatullah S. Ethnopharmacological studies on Allspice Pimenta dioica in laboratory animals. Pharm Biol. Allahghadri T, Rasooli I, Owlia P, Nadooshan M. J, Ghazanfari T, Taghizadeh M, Astaneh S. Amagase H, Sakamoto K, Segal E.

R, Milner J. Dietary rosemary suppresses 7,dimethylbenz a anthracene binding to rat mammary cell DNA.

J Nutr. Anilakumar K. R, Nagaraj N. S, Santhanam K. Effect of coriander seeds on hexachlorocyclo- hexane induced lipid peroxidation in rat liver. Nutr Res. Antosiewicz J, Ziolkowski W, Kar S, Powolny A. A, Singh S. Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents.

Aruna K, Rukkumani R, Menon V. Role of Cuminum cyminum on ethanol and preheated sunflower oil induced lipid peroxidation. J Herbs Spices Med Plants. Aruna K, Sivaramakrishnan V. Plant products as protective agents against cancer. Indian J Exp Biol. Aung H. H, Wang C. Z, Ni M, editors.

Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp Oncol. Aydin S, Basaran A. A, Basaran N. The effects of thyme volatiles on the induction of DNA damage by the heterocyclic amine IQ and mitomycin C.

Mutat Res. Bakshi H. A, Sam S, Feroz A, Ravesh Z, Shah G. A, Sharma M. Crocin from Kashmiri saffron Crocus sativus induces in vitro and in vivo xenograft growth inhibition of Dalton's lymphoma DLA in mice.

Asian Pac J Cancer Prev. Banerjee S, Sharma R, Kale R. K, Rao A. Influence of certain essential oils on carcinogen- metabolizing enzymes and acid-soluble sulfhydryls in mouse liver. Nutr Cancer. Bar-Sela G, Epelbaum R, Schaffer M. Curcumin as an anti-cancer agent: Review of the gap between basic and clinical applications.

Curr Med Chem. Bhattacharjee S, Rana T, Sengupta A. Inhibition of lipid peroxidation and enhancement of GST activity by cardamom and cinnamon during chemically induced colon carcinogenesis in Swiss albino mice. Bidinotto L. T, Spinardi-Barbisan A. L, Rocha N. S, Salvadori D. M, Barbisan L.

Effects of ginger Zingiber officinale Roscoe on DNA damage and development of urothelial tumors in a mouse bladder carcinogenesis model. Environ Mol Mutagen. Billing J, Sherman P.

Antimicrobial functions of spices: Why some like it hot. Q Rev Biol. Bode A. M, Ma W. Y, Surh Y. J, Dong Z. Inhibition of epidermal growth factor-induced cell trans-formation and activator protein 1 activation by [6]-gingerol.

Cancer Res. Buzzanell P. J, Gray F. The spice market in the united states: Recent developments and prospects. USDA Agriculture Information Bulletin Cao G, Prior R. Comparison of different analytical methods for assessing total antioxidant capacity of human serum.

Clin Chem. Cao H, Urban J. Cinnamon polyphenol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages.

Chen C. J Agric Food Chem. Chiang L. C, Ng L. T, Cheng P. W, Chiang W, Lin C. Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clin Exp Pharmacol Physiol. Chrubasik S, Pittler M. H, Roufogalis B. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles.

Cope K, Seifried H, Seifried R, Milner J, Kris-Etherton P, Harrison E. A gas chromatography- mass spectrometry method for the quantitation of N-nitrosoproline and N-acetyl-S-allylcysteine in human urine: Application to a study of the effects of garlic consumption on nitrosation.

Anal Biochem. Das I, Chakrabarty R. N, Das S. Saffron can prevent chemically induced skin carcinogenesis in Swiss albino mice.

Das I, Das S, Saha T. Saffron suppresses oxidative stress in DMBA-induced skin carcinoma: A histopathological study. Acta Histochem. Dasgupta T, Rao A. R, Yadava P. Chemomodulatory efficacy of basil leaf Ocimum basilicum on drug metabolizing and antioxidant enzymes, and on carcinogen-induced skin and forestomach papillomagenesis.

Davies M, Robinson M, Smith E, Huntley S, Prime S, Paterson I. Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways. J Cell Biochem. Deeptha K, Kamaleeswari M, Sengottuvelan M, Nalini N.

Dose dependent inhibitory effect of dietary caraway on 1,2-dimethylhydrazine induced colonic aberrant crypt foci and bacterial enzyme activity in rats. Invest New Drugs. Dhar A, Mehta S, Dhar G, editors.

Crocetin inhibits pancreatic cancer cell proliferation and tumor progression in a xenograft mouse model. Mol Cancer Ther. Dhuley J. Anti-oxidant effects of cinnamon Cinnamomum verum bark and greater cardamom Amomum subulatum seeds in rats fed high fat diet.

Dinarello C. Anti-inflammatory agents: Present and future. Domaracky M, Rehak P, Juhas S, Koppel J. Effects of selected plant essential oils on the growth and development of mouse preimplantation embryos in vivo.

Physiol Res. Dorrie J, Sapala K, Zunino S. Carnosol-induced apoptosis and downregulation of Bcl-2 in B-lineage leukemia cells. Cancer Lett. Dragan S, Nicola T, Ilina R, Ursoniu S, Kimar A, Nimade S. Role of multi-component functional foods in the complex treatment of patients with advanced breast cancer.

Rev Med Chir Soc Med Nat Iasi. Dragland S, Senoo H, Wake K, Holte K, Blomhoff R. Several culinary and medicinal herbs are important sources of dietary antioxidants.

Epstein J, Sanderson I. R, Macdonald T. Curcumin as a therapeutic agent: The evidence from in vitro, animal and human studies. Br J Nutr. Esiyok D, Otles S, Akcicek E. Herbs as a food source in Turkey. Eslick G. Helicobacter pylori infection causes gastric cancer? A review of the epidemiological, meta- analytic and experimental evidence.

World J Gastroenterol. Farinha P, Gascoyne R. Helicobacter pylori and MALT lymphoma. Food and Drug Administration Chapter 5: Foods, Colors and Cosmetics Sub-Chapter Condiment Industry.

htm; Fung J, Lai C. L, Yuen M. Hepatitis B and C virus-related carcinogenesis. Clin Microbiol Infect. Gali-Muhtasib H, Roessner A, Schneider-Stock R. Thymoquinone: A promising anti-cancer drug from natural sources.

Int J Biochem Cell Biol. Han E. H, Hwang Y. P, Jeong T. C, Lee S. S, Shin J. G, Jeong H. Eugenol inhibits 7, dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: Bifunctional effects on CYP1 and NAD P H:quinone oxidoreductase.

FEBS Lett. T, Wang M, Wei G. J, Huang T. C, Huang M. Chemistry and antioxidative factors in rosemary and sage. Huang M. T, Ho C.

T, Wang Z. Y, editors. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Huang C, Ma W. Y, Dong Z. Mol Cell Biol. Ihlaseh S.

M, de Oliveira M. L, Teran E, de Camargo J. L, Barbisan L. Chemopreventive property of dietary ginger in rat urinary bladder chemical carcinogenesis.

World J Urol. Ippoushi K, Azuma K, Ito H, Horie H, Higashio H. Life Sci. Ippoushi K, Takeuchi A, Ito H, Horie H, Azuma K. Antioxidative effects of daikon sprout Raphanus sativus L. and ginger Zingiber officinale Roscoe in rats. Food Chem.

Ishikawa T. Clinical features of hepatitis B virus-related hepatocellular carcinoma. Iyer A, Panchal S, Poudyal H, Brown L. Pollutants may be found on both organic and non-organic foods, so all vegetables and fruit should be washed well.

Learn more about pesticides. But diets that include lean white meat and fish, and red meat in small amounts, can also be healthy. Home Cancer information Reduce your risk Eat well Eating well extras to consider.

Eating well extras to consider. Have questions about vitamin D supplements, antioxidants, organic foods or vegetarian diets? Let us help you navigate the information available on these topics. Should I take a vitamin D supplement? The best way to get all the vitamins and minerals you need is to make healthy food choices.

The one exception: vitamin D Vitamin D is needed for healthy bones and muscles, especially in children and the elderly. Vitamin D and cancer. Can you have too much of a good thing? What are antioxidants and phytochemicals? What are antioxidants? Some types of antioxidants are: vitamin A vitamin C vitamin E selenium.

What are phytochemicals? Some types of phytochemicals are: carotenoids beta carotene, lycopene and lutein flavonoids indoles isoflavones. Why do we need them? Can coffee and tea protect against cancer?

Coffee Research suggests that drinking coffee may help protect against uterine and liver cancer. Tea Black and green teas are rich in antioxidants. Some research suggests that tea may help protect against cancer because of these antioxidants, but the research comes mainly from animal studies.

Herbal tea Herbal teas are made up of a combination of different flowers, herbs and spices. Hot beverage tip. What are genetically modified foods GMOs? Are GMOs safe? GMOs and cancer. Is organic better? Is a vegetarian diet healthy? Our enewsletter.

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Medicinal ssupplements are mushrooms that are used as Immunity-boosting strategies. They have Herbal anti-cancer supplements used to treat infection for Dairy-free bread supplemetns Herbal anti-cancer supplements, mostly abti-cancer Asia. Herbal anti-cancer supplements, medicinal mushrooms Vegan snacks for on-the-go also used to treat lung diseases and cancer. For more than 30 years, medicinal mushrooms have been approved as an addition to standard cancer treatments in Japan and China. In these countries, mushrooms have been used safely for a long time, either alone or combined with radiation or chemotherapy. In Asia, there are more than types of mushrooms used to treat cancer. Some of the more common ones are Ganoderma lucidum reishiTrametes versicolor or Coriolus versicolor turkey tailLentinus edodes shiitakeand Grifola frondosa maitake. Calling antti-cancer number connects you with supplements Patient Dairy-free bread at The Mesothelioma Antu-cancer, Herbal anti-cancer supplements nation's Dairy-free bread trusted Herbal anti-cancer supplements resource. Our Patient Advocates Hetbal Dairy-free bread Heart care assistance you or Herbap loved one through the anti-czncer to take after a mesothelioma diagnosis. Our team has a combined experience of more than 30 years in assisting cancer patients, and includes a medical doctor, an oncology registered nurse and a U. For example, some herbs can prevent chemotherapy and radiation therapy from killing cancer cells. Certain herbs enhance the effect of chemotherapy in a toxic way that leads to unwanted side effects. Doctors recommend patients avoid herbs during treatment. Clinical trials that combine herbal medicine with cancer therapies are relatively new to the United States.


Common Herbs May Hold Key To Tumor-Killing Cancer Treatment

Author: Majinn

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